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TranscriptomicsTranscription profiling of mouse age-related hearing loss cochlea in DBA/2J
Age-related hearing loss (AHL) is the progressive loss of auditory function with aging. The DBA/2J (DBA) mice have been used as a model of AHL and undergoes progressive, age-related hearing loss by 12 weeks of age. Here we analyzed cochlear gene expression of 7-week-old and 36-week-old DBA mice usin...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6045 | biostudies-arrayexpress
GenomicsSPATC1L variants associated with age-related and hereditary hearing loss
Next-Generation Sequencing techniques (i.e, targeted re-sequencing and whole exome sequencing) have been employed for the study of two Italian patients affected by age-related hearing loss and of an Italian family affected by hereditary hearing loss. Data analysis led to the identification of three ...
EGAS00001003047 | EGA
GenomicsHearing loss in adults from South Carolina
DNA from ten individuals from South Carolina with progressive hearing loss will be subjected to exome sequencing
EGAS00001000157 | EGA
GenomicsExome Resequencing of Progressive Hearing Loss
Exome resequencing of progressive hearing loss.
EGAS00001000001 | EGA
GenomicsGene Discovery in Age Related Hearing Loss
The aim is to find new candidate genes associated with progressive hearing loss
EGAS00001000295 | EGA
TranscriptomicsTranscription profiling of mouse cochlea to investigate the role of mtDNA mutations in age-related hearing loss in mice carrying a mutator DNA polymerase gamma
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related disorders. Previously, we created mice expressing a proofreading-deficient version of the mtDNA polymerase gamma (Polg) which accumulate age-related mtDNA mutations and display premature aging. Here we performed microarray g...
ORGANISM(S): Mus musculus 
2008-11-07 | E-GEOD-4866 | biostudies-arrayexpress
Proteomics"Time-resolved quantitative proteomic analysis of the developing otic vesicle reveals putative congenital hearing loss candidates and a novel role for Tgfbi
A large number of congenital hearing loss cases have an unknown genetic etiology. So far, transcriptomic approaches have successfully identified many candidate regulators of otic development, little is known about the abundance of their protein products during the development of the inner eat. Herei...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2023-10-24 | PXD041991 | Pride
Otic development Congenital hearing loss Xenopus laevis Temporal Extracellular matrix 
TranscriptomicsExome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss
Background The genetic diversity of loci and mutations underlying hereditary hearing loss is an active area of investigation. To identify loci associated with predominantly non-syndromic sensorineural hearing loss, we performed exome sequencing of families and of single probands, as well as copy num...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-64088 | biostudies-arrayexpress
MetabolomicsAn LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) ...

2021-10-06 | MTBLS2418 | MetaboLights
TranscriptomicsMap the causative gene of hearing loss in Chinese Rongchang pigs by GWAS
Whole genome genotyping (WGG) arrays are the powerful tools for GWAS in farm animal. Here we take advantage of the commercial Illumina PorcineSNP60 BeadChips, a mapping population including 101 individuals were genotyped. Association analysis and linkage analysis were followed to map the causative g...
ORGANISM(S): Sus scrofa 
2015-05-01 | E-GEOD-67618 | biostudies-arrayexpress
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