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MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
MetabolomicsButyrate ameliorate doxorubicin-induced heart failure via microbiota/ metabolites-gut-Heart axis
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
2025-09-13 | MTBLS11830 | MetaboLights
MetabolomicsGRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis

BACKGROUND: Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we iden...

2025-10-19 | MTBLS13178 | MetaboLights
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
MetabolomicsButyrate ameliorate doxorubicin-induced heart failure via microbiota/ metabolites-gut-Heart axis
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
2025-09-12 | MTBLS11819 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15770 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
MetabolomicsCross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights
MetabolomicsZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1
Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicate...
2026-09-28 | MTBLS15833 | MetaboLights
MetabolomicsMetabolomics of heart tissue at baseline and following myocardial infarction
A comprehensive analysis of the heart metabolome was conducted at 60 min reperfusion post ischaemia. This analysis employed LC-MS/MS in order to provide a detailed examination of the metabolic processes occurring within the heart. The focus of this analysis was placed on glycolysis, the tricarboxyli...
2026-04-30 | MTBLS14417 | MetaboLights
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