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MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
MetabolomicsButyrate ameliorate doxorubicin-induced heart failure via microbiota/ metabolites-gut-Heart axis
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
2025-09-13 | MTBLS11830 | MetaboLights
MetabolomicsFOXK1 and FOXK2 Promote Cardiomyocyte Proliferation and Heart Regeneration
Promoting the proliferation of endogenous cardiomyocytes represents a promising strategy for treating cardiac injuries. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration. Here we identify that FOXK1 and FOXK2 act a...
2025-02-13 | MTBLS12191 | MetaboLights
MetabolomicsButyrate ameliorate doxorubicin-induced heart failure via microbiota/ metabolites-gut-Heart axis
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
2025-09-12 | MTBLS11819 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
MetabolomicsDiscovery and validation of potential serum biomarkers for heart failure by untargeted metabolomics

Detection of biomarkers was extremely important for the early diagnosis, prognosis and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy controls (HC), and to diagnose HF qualita...

2025-07-18 | MTBLS9586 | MetaboLights
MetabolomicsMetabolomics of heart tissue at baseline and following myocardial infarction
A comprehensive analysis of the heart metabolome was conducted at 60 min reperfusion post ischaemia. This analysis employed LC-MS/MS in order to provide a detailed examination of the metabolic processes occurring within the heart. The focus of this analysis was placed on glycolysis, the tricarboxyli...
2026-04-30 | MTBLS14417 | MetaboLights
MetabolomicsLandscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study

Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites have critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36...

2023-10-23 | MTBLS8183 | MetaboLights
MetabolomicsSevere hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice
Abstract Aim: Circulating triglyceride and triglyceride-rich lipoprotein (TRL) accumulation is increasingly recognized as a residual atherosclerotic risk, but their specific effect in cardiac remodeling and heart failure (HF) remain largely unexplored. Here we investigated this issue in Gpihbp1 knoc...
2026-06-11 | MTBLS14749 | MetaboLights
MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14243 | MetaboLights
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