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TranscriptomicsA receptor tyrosine kinase network comprised of FGFRs, EGFR, ERBB2, and MET drives growth and survival of HNSCC cell lines.
We have previously shown that some gefitinib insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole genome loss-of-function screen to identify genes whose knockdown potentiated th...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39305 | biostudies-arrayexpress
UnknownMicro and Macroscale Drivers of Nutrient Concentrations in Urban Streams in South, Central and North America.
Not available
S-EPMC5035044 | biostudies-literature
TranscriptomicsHypoxia regulates alternative splicing of HIF and non-HIF target genes
Alternative RNA splicing analysis in Hep3B cell cultured under 21% (N1,3,5) or 1.2% (H2,4,6) oxygen Hypoxia is a common characteristic of many solid tumors. The hypoxic microenvironment stabilizes hypoxia-inducible transcription factor 1? (HIF1?) and 2? (HIF2?) to activate gene transcription, which ...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-57613 | biostudies-arrayexpress
UnknownHypoxia regulates alternative splicing of HIF and non-HIF target genes.
Not available
S-EPMC4163527 | biostudies-literature
UnknownRapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.
Not available
S-EPMC2994708 | biostudies-literature
UnknownFGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area.
Not available
S-EPMC4200677 | biostudies-literature
UnknownA miRNA Panel Predicts Sensitivity of FGFR Inhibitor in Lung Cancer Cell Lines.
Not available
S-EPMC6339511 | biostudies-literature
TranscriptomicsNSCLC cells treated with Gefitinib
About 10% of all NSCLC patients respond to gefitnib treatment and all of these patients will acquire resistance to the EGFR TKI. We used microarray to look at global gene expression changes in untreated cells vs gefitinib treated cells to identify key characters for the acquisition of resistance. NS...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-23206 | biostudies-arrayexpress
TranscriptomicsA mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop
Despite initial and often dramatic responses of epidermal growth factor receptor (EGFR)-addicted lung tumors to the EGFR-specific tyrosine kinase inhibitors (TKIs), gefitinib and erlotinib, nearly all develop resistance and relapse. To explore novel mechanisms mediating acquired resistance, we emplo...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-79688 | biostudies-arrayexpress
UnknownWild yeast isolation by middle school students reveals features of North American oak populations of Saccharomyces cerevisiae and Kluyveromyces lactis.
Not available
S-EPMC11244913 | biostudies-literature
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