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TranscriptomicsBrg1 promotes both tumor suppressive and oncogenic activities at distinct stages of Pancreatic cancer formation
Pancreatic Ductal Adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a “ductal like” state during PanIN-PDA formation. Here, we demonstrate ...
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-65315 | biostudies-arrayexpress
TranscriptomicsIncomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES) cells, but recent reports indicate that there may be important differences between them. We carried out a systematic comparison of human iPS cells generated from hepatocytes (representative of endoderm), skin fi...
ORGANISM(S): Homo sapiens 
2011-04-17 | E-GEOD-23034 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of pancreatic beta cells during maturation and with function-inactivating mutations
Islet β-cells from newborn mammals need a maturation process to become mature functional beta cells. The detailed molecular mechanisms were not completely understood. This study was designed to reveal the dynamic gene expression changes during pancreatic beta-cell maturation in postnatal mice. We al...
ORGANISM(S): Mus musculus 
2018-04-01 | E-MTAB-6615 | biostudies-arrayexpress
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