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UnknownEffectiveness of psychosocial interventions to improve the mental health in men who have sex with men: a systematic review and meta-analysis.

Background

Men who have sex with men (MSM) are vulnerable to mental health problems. Some psychosocial interventions showed different effects on various mental health aspects, but the exact pooled effect size was uncertain. This study aimed to evaluate the effectiveness of psychosocial inter...
S-EPMC12497705 | biostudies-literature
UnknownAir pollution abatement from Green-Blue-Grey infrastructure.
Green-blue-grey infrastructure (GBGI) offers environmental benefits in urban areas, yet its impact on air pollution is under-researched, and the literature fragmented. This review evaluates quantitative studies on GBGI's capability to mitigate air pollution, compares their specific pollutant removal...
S-EPMC11998961 | biostudies-literature
UnknownHeterogeneity of resting-state EEG features in juvenile myoclonic epilepsy and controls.
Abnormal EEG features are a hallmark of epilepsy, and abnormal frequency and network features are apparent in EEGs from people with idiopathic generalized epilepsy in both ictal and interictal states. Here, we characterize differences in the resting-state EEG of individuals with juvenile myoclonic e...
S-EPMC9301584 | biostudies-literature
UnknownVariability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis.
Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. It is unclear whether inter-individual variability in glutamate is greater in schizophrenia than the general population. We conducted meta-analyses to assess (1) variability of glut...
S-EPMC10575771 | biostudies-literature
UnknownNeurofeedback for Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.

Importance

Neurofeedback has been proposed for the treatment of attention-deficit/hyperactivity disorder (ADHD) but the efficacy of this intervention remains unclear.

Objective

To conduct a meta-analysis of randomized clinical trials (RCTs) using probably blinded (ie, rated by individ...
S-EPMC11800020 | biostudies-literature
UnknownEstrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.

Background

Pulmonary arterial hypertension (PAH) is a proliferative disease of the pulmonary vasculature that preferentially affects women. Estrogens such as the metabolite 16α-hydroxyestrone (16αOHE) may contribute to PAH pathogenesis, and alterations in cellular energy metabolism associate...
S-EPMC4698046 | biostudies-literature
UnknownComparison of DNA methylation based classification models for precision diagnostics of central nervous system tumors.
As part of the advancement in therapeutic decision-making for brain tumor patients at St. Jude Children's Research Hospital (SJCRH), we developed three robust classifiers, a deep learning neural network (NN), k-nearest neighbor (kNN), and random forest (RF), trained on a reference series DNA-methyla...
S-EPMC11447224 | biostudies-literature
UnknownPD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor.
The killing of tumor cells by CD8+ T cells is suppressed by the tumor microenvironment, and increased expression of inhibitory receptors, including programmed cell death protein-1 (PD-1), is associated with tumor-mediated suppression of T cells. To find cellular defects triggered by tumor...
S-EPMC7784968 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.

Background

Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the se...
S-EPMC7787219 | biostudies-literature
UnknownComprehensive molecular characterization of pediatric radiation-induced high-grade glioma.
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. We performed DNA methylation profiling, RNA-seq, and DNA sequencing on 32 RIG tumors and an in vitro drug screen in two RIG cell lines. We report that based on DNA methylation, RIGs cluster p...
S-EPMC8452624 | biostudies-literature
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