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TranscriptomicsFeedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-9200 | biostudies-arrayexpress
TranscriptomicsHuman GBM tumor vs Normal Human DNA
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-9177 | biostudies-arrayexpress
GenomicsMelanoma Genome Sequencing Project

Melanoma is the most prevalent cause of skin cancer morbidity and mortality. In order to characterize the full range of somatic mutations that may drive the growth of melanoma, we are sequencing tumor and normal DNA from a set of roughly 150 melanomas. For the majority of samples (approximately 9...

phs000452.v1.p1 | EGA
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