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TranscriptomicsMolecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Introduction: Five different molecular subtypes of breast cancer have been identified through gene expression profiling. Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct me...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22210 | biostudies-arrayexpress
TranscriptomicsCharacterization of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumors
Amplification of chromosomal region 11q13, containing the cell cycle regulatory gene CCND1, is frequently found in breast cancer and other malignancies. It is associated with the favourable oestrogen receptor (ER) positive breast tumour phenotype, but also with poor prognosis and treatment failure. ...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-32578 | biostudies-arrayexpress
TranscriptomicsIdentification of subtypes in HER2-positive breast cancer reveals a gene signature prognostic of outcome
Purpose HER2 gene amplification or protein overexpression (HER2+) defines a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. We aimed to investigate the heterogeneous biological appearance and clinical behavior of HER2+ tumors using molecular profilin...
ORGANISM(S): Homo sapiens 
2010-03-16 | E-GEOD-18328 | biostudies-arrayexpress
TranscriptomicsThe retinoblastoma gene is targeted for rearrangements in BRCA1-deficient basal-like breast cancer.
Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecular...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-25307 | biostudies-arrayexpress
TranscriptomicsGenomic Subtypes of Breast Cancer Identified by Array Comparative Genomic Hybridization
Breast cancer is a profoundly heterogeneous disease with respect to biological and clinical behavior. Gene expression profiling has been used to dissect this complexity and stratify tumors into intrinsic gene expression subtypes associated with distinct biology, patient outcome and different genomic...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22133 | biostudies-arrayexpress
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