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ProteomicsRibosome collisions trigger cis-acting feedback inhibition of translation initiation
Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing ribosomes. Collided ribosomes are specifically recognized by ZNF598 to initiate protein and mRNA quality control pathways. Here we found using quantitative proteomics of collided ribosomes that EDF1 is a ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD020239 | Pride
Human Ribosome stalling Quality control 
ProteomicsMechanism of ribosome-associated mRNA degradation during tubulin autoregulation
Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis. The availability of free tubulin subunits impacts polymerization dynamics and microtubule function. When cells sense excess free tubulin, they trigger degradation of the encoding mRNAs, which requires rec...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD041096 | Pride
Orbitrap eclipse Q exactive plus Human lc-ms/ms 
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