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Genomicsproj022_chipseq
The mechanisms that recruit the major Polycomb-group (PcG) complexes PRC1 and PRC2 to target sites in vertebrate cells are not well understood. Building on recent studies that have determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that in methylation ...
ORGANISM(S): Mus musculus 
2014-05-23 | E-MTAB-2481 | biostudies-arrayexpress
Transcriptomics[E-MTAB-599] Mouse Transcriptome
Sequencing the transcriptome of DBAxC57BL/6J mice. To study the regulation of transcription, splicing and RNA turnover we have sequenced the transcriptomes of tissues collected DBAxC57BL/6J mice. We strongly encourage researchers to contact us if there is any queries about referencing or publishing ...
ORGANISM(S): Mus musculus 
2011-07-14 | GSE30617 | GEO
Transcriptomicsproj008_submission
Interferon regulatory factor (IRF) 5 has a major role in defining inflammatory macrophage polarization, but the molecular mechanisms of its function as a transcriptional regulator of inflammatory genes are not fully understood. Here, we characterise the sites of IRF5 recruitment in inflammatory macr...
ORGANISM(S): Mus musculus 
2014-08-20 | E-MTAB-2032 | biostudies-arrayexpress
Genomicsproj008_chipseq_experiment2
Interferon regulatory factor (IRF) 5 has a major role in defining inflammatory macrophage polarization, but the molecular mechanisms of its function as a transcriptional regulator of inflammatory genes are not fully understood. Here, we characterise the sites of IRF5 recruitment in inflammatory macr...
ORGANISM(S): Mus musculus 
2014-09-01 | E-MTAB-2661 | biostudies-arrayexpress
Genomicsproj008_chipseq
Interferon regulatory factor (IRF) 5 has a major role in defining inflammatory macrophage polarization, but the molecular mechanisms of its function as a transcriptional regulator of nflammatory genes are not fully understood. Here, we characterise the sites of IRF5 recruitment in inflammatory macro...
ORGANISM(S): Mus musculus 
2014-08-20 | E-MTAB-2033 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy
Early chemotherapy for advanced/metastatic non-castration resistant prostate cancer (PCa) may improve overall patient survival. We studied the safety, tolerability and early efficacy of up-front docetaxel chemotherapy and androgen deprivation therapy (ADT) versus ADT alone for patients with newly-d...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-51005 | biostudies-arrayexpress
TranscriptomicsThe Wnt/β-catenin-signaling pathway is modulated by androgen ablation therapy for advanced clinical prostate cancer and contributes to androgen independent cell growth
Androgen ablation therapy (AAT) is standard treatment for locally-advanced/metastatic prostate cancer (PCa). Many patients develop castration-resistance (CRPCa) after ~2-3 years, with a poor prognosis. The molecular mechanisms underlying CRPCa progression are unclear. mRNA-Seq was performed on tu...
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-48403 | biostudies-arrayexpress
GenomicsAire secures the transcription of polycomb marked genes to complete a comprehensive program of promiscuous gene expression in the thymic epithelial cell lineage
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-53111 | biostudies-arrayexpress
TranscriptomicsGene expression in thymic epithelial cells [RNA-seq]
This study set out to assay the (polyA+) transcriptomes of specific FACS sorted populations of mouse thymic epithelial cells (TEC). Two biological replicates of each of seven murine TEC populations were FACS sorted and sequenced.
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-53110 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes - microarray study
Investigating the response of long non-coding RNA expression to LPS stimulation in human monocytes. This experiment is related to the RNA-seq study E-MTAB-2399.
ORGANISM(S): Homo sapiens 
2014-04-25 | E-MTAB-2408 | biostudies-arrayexpress
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