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TranscriptomicsMolecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia
Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and arra...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-25411 | biostudies-arrayexpress
TranscriptomicsExpression analysis of 13 squamous cell carcinomas arising in the vulva
The genome of 14 vulvar SCC was analyzed by aCGH and microarray to identify common imbalances present in the tumors as well as which genes were deregulated. Overall there was a good concordance between the imbalances scored by aCGH and the level of gene expression found by microarray, i.e., the gene...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-GEOD-38228 | biostudies-arrayexpress
TranscriptomicsPilot-study for a novel universal tool for detection of oncogenic fusion transcripts
A novel oligonucleotide microarray design is described whereby one can screen for all known oncogenic fusion transcripts by one microarray hybridization. Measurements of chimeric transcript junctions are combined with exon-wise measurements of individual fusion partners. Keywords: Nimblegen custom-...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-14435 | biostudies-arrayexpress
TranscriptomicsGenomic Aberrations in Paediatric Gliomas and Embryonal Tumours
The pathogenesis of paediatric central nervous system tumours is still poorly understood. In an attempt to increase the knowledge of the genetic mechanisms underlying these tumours, we performed genome-wide screening of 17 paediatric gliomas and embryonal tumours using a combination of G-band karyot...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-27671 | biostudies-arrayexpress
TranscriptomicsMultiple chromosomal monosomies are characteristic of giant cell ependymoma
Giant cell ependymoma (GCE), a rare ependymoma subtype, was only recently recognised as a separate diagnostic entity with variations both in malignant potential and in course of disease. The pathogenetic mechanisms behind ependymomas remain unknown. Only one karyotyped GCE has so far been reported. ...
ORGANISM(S): Homo sapiens 
2010-08-30 | E-GEOD-23065 | biostudies-arrayexpress
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