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TranscriptomicsDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit. Here, we have modeled this...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-37286 | biostudies-arrayexpress
TranscriptomicsExpression in irradiated MEFs exposed to murine acute lymphoblastic leukemia cells
Primary pre-B acute lymphoblastic (ALL) cells do not proliferate long-term ex vivo without the presence of stromal support. We developed and use an ex vivo co-culture model, consisting of mouse leukemic pre-B Bcr/Abl-expressing ALL cells grown with mitotically inactivated mouse embryonic fibroblasts...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33329 | biostudies-arrayexpress
TranscriptomicsEffect of imatinib on philadelphia chromosome positive acute lymphoblastic leukemia
The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. In this study, the tyrosine kinase inhibitor imatinib was used for pharmacological inhibition of BCR-ABL1. Gene exp...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-23743 | biostudies-arrayexpress
TranscriptomicsInhibition of BCL6-dependent gene expression in Philadelphia chromosome positive acute lymphoblastic leukemia
The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. Tyrosine kinase inhibitors (TKI) are widely used to treat patients with leukemia driven by BCR-ABL1 and other oncog...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-24381 | biostudies-arrayexpress
TranscriptomicsRecruitment of BCL6 to target genes in Philadelphia chromosome positive acute lymphoblastic leukemia
The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. Tyrosine kinase inhibitors (TKI) are widely used to treat patients with leukemia driven by BCR-ABL1 and other oncog...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-24404 | biostudies-arrayexpress
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