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TranscriptomicsThe Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation r...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-31354 | biostudies-arrayexpress
TranscriptomicsshRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance
We used a mouse model of human AML induced by the MLL-AF9 fusion oncogene, and an epigenetic shRNA library to screen for novel potential drug targets. One of the best candidate drug targets identified in these screens was Jmjd1c. Depletion of Jmjd1c impairs growth and colony formation of mouse MLL-A...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-50048 | biostudies-arrayexpress
TranscriptomicsHelin M.musculus Identification of genes repressed by CBX8 and BMI1
The polycomb group proteins form large repressive complexes. It has recently become evident, via ChIP on chip analysis, that the polycomb complexes, PRC1 and PRC2, target a large number of genes (Boyer et al., 2006; Bracken et al., 2006; Tolhuis et al., 2006), which are involved in cell fate decisio...
ORGANISM(S): Mus musculus 
2007-03-05 | E-MEXP-793 | biostudies-arrayexpress
TranscriptomicsshRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance (Agilent)
We used a mouse model of human AML induced by the MLL-AF9 fusion oncogene, and an epigenetic shRNA library to screen for novel potential drug targets. One of the best candidate drug targets identified in these screens was Jmjd1c. Depletion of Jmjd1c impairs growth and colony formation of mouse MLL-A...
ORGANISM(S): Mus musculus 
2014-01-23 | E-GEOD-54311 | biostudies-arrayexpress
GenomicsTet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (ChIP/DIP-Seq data)
We analyzed the genome-wide binding of Tet1 in control (shScr) and Tet1 knockdown (shTet1) mouse ES cells using two different Tet1 antibodies (Tet1-C and Tet1-N). Furthermore, we generated genome-wide mapping of hydroxymethyl cytosine (hmC) and methyl cytosine (mC). We find that hmC, in contrast to ...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24841 | biostudies-arrayexpress
TranscriptomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58023 | biostudies-arrayexpress
UnknownCompressibility of Lithium Hexafluorophosphate Solutions in Two Carbonate Solvents.
Not available
S-EPMC10108564 | biostudies-literature
UnknownThe polycomb group protein Suz12 is required for embryonic stem cell differentiation.
Not available
S-EPMC1899991 | biostudies-literature
GenomicsJarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq]
We analyzed the genome-wide binding profile of Jarid1b in mouse ESCs. We find that Jarid1b localizes mainly to transcription start sites, of which more than 50% are also bound by Polycomb proteins and are enriched for genes encoding developmental regulators. Furthermore, we generated genome-wide map...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31966 | biostudies-arrayexpress
TranscriptomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [RNA-seq_differentiation]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58017 | biostudies-arrayexpress
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