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UnknownClinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).
Not available
S-EPMC5455706 | biostudies-literature
UnknownCediranib for metastatic alveolar soft part sarcoma.
Not available
S-EPMC3677840 | biostudies-literature
TranscriptomicsExpression data for Cediranib in Metastatic ASPS
Gene expression from pre- and post- Cediranib treated patients with metastatic Alveolar Soft Part Sarcoma (ASPS) Paired tumor biopsies from 6 patients were collected. Samples were collected at baseline and 3 to 5 days following treatment. The patients are all enrolled in the replicate cohort of a Na...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-32569 | biostudies-arrayexpress
UnknownInhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.
Not available
S-EPMC7009740 | biostudies-literature
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
UnknownSTA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
Not available
S-EPMC5323173 | biostudies-literature
TranscriptomicsExpression data from SDH-disabled GIST
Pediatric GIST commonly harbors a disabled succinate dehydrogenase complex (SDH), which yields tumors with highly conserved genomes but characteristic epigenomic signatures. Mysteriously, nearly half of such SDH-deficient GIST, including tumors from Carney Triad patients, lack identifiable mutations...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-56670 | biostudies-arrayexpress
UnknownThe mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors.
Not available
S-EPMC7255694 | biostudies-literature
TranscriptomicsGlobal methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer
The insulin-like growth factor-I (IGF-IR) and androgen (AR) receptors are important players in prostate cancer biology. Functional interactions between the IGF-I and androgen signaling pathways seem to have crucial roles in the progression of prostate cancer from early (benign) to advanced (metastat...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-34042 | biostudies-arrayexpress
UnknownComprehensive genomic characterization of squamous cell lung cancers.
Not available
S-EPMC3466113 | biostudies-literature
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