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50 Helminth Genomes Initiative
Parasitic worms (helminths) represent a major class of human and animal pathogens that impact agriculture and economies worldwide. Over the past few decades, Mass spectrometry (MS)-based glycomics studies have revealed that helminths possess an abundance of complex and unique glycoconjugates that in...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2025-12-17 | PXD068910 | Pride
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of chronic intestinal helminth infection, we identify helminthic glutamate dehydrogenase (heGDH) as an essential factor for parasite chronicity by using antibody mediated neutralization...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD044102 | Pride
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