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MetabolomicsLinking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in pediatric hematopoietic stem cell transplantation

BACKGROUND: Hematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse clinical outcomes can develop post-transplantation including graft-versus-host disease and infections, which remain the major cau...

2022-05-11 | MTBLS4065 | MetaboLights
MetabolomicsGut microbiome and metabolome dynamics as predictors of clinical outcomes in hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) induces significant alterations in the gut microbiome and metabolome, which influence transplant-related complications and surviv-al. This study longitudinally analyzed gut microbiota and metabolites at pre- (T1), peri- (T2), and post-transplant (T3) st...
2025-07-30 | MTBLS12365 | MetaboLights
MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
TranscriptomicsMouse cytokine antibody array
Tumors of hematopoietic stem cell transplantation (HSCT) or control mice were collected at day 14 post transplantation. Comprehensive analysis of cytokine levels were performed by using commercially available RayBio Mouse Cytokine Array G series III and IV (RayBiotech, Inc.) according to manufacture...
ORGANISM(S): Mus musculus 
2013-08-28 | E-MTAB-1761 | biostudies-arrayexpress
GenomicsBLUEPRINT DNA methylation profiles of graft donors in allogenic hematopoietic stem cell transplantation
Allogenic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication following HSCT. Current diagnostic biomarkers that correlate with aGVHD severity, progression, and t...
EGAS00001001287 | EGA
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 1)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS204 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 2)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS205 | MetaboLights
TranscriptomicsInterleukin-10-anergized T-cell infusion provides immune reconstitution without severe graft-versus-host disease after haploidentical hematopoietic stem cell transplantation
Regulatory T cells restore tolerance in preclinical models of immune-mediated diseases and are therefore a promising alternative to conventional immune-suppression for preventing graft-versus-host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Adaptiv...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-21885 | biostudies-arrayexpress
TranscriptomicsProstaglandin dose response on hematopoietic stem cells (25 & 37 deg C)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with del...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-48541 | biostudies-arrayexpress
GenomicsMethylation_450K_EpiMatch - samples
BLUEPRINT EpiMatch: harnessing epigenetics for hematopoietic stem cell transplantation
EGAD00010000831 | EGA
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