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GenomicsWidespread transcription at neuronal activity-regulated enhancers
We used genome-wide sequencing methods to study stimulus-dependent enhancer function in neurons. We identified ~12,000 neuronal activity-regulated enhancers that are bound by the general transcriptional co-activator CBP in an activity-dependent manner. A function of CBP at enhancers may be to recrui...
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-21161 | biostudies-arrayexpress
GenomicsPromoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. Here, we find that depletion of the nucleosome remodeling and deacetylation (NuRD) complex in the cerebellar cortex by in v...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-57758 | biostudies-arrayexpress
GenomicsChromatin Remodeling Inactivates Activity Genes and Regulates Neural Coding
Activity-dependent transcription influences neuronal connectivity, but the roles and mechanisms of inactivation of activity-dependent genes have remained poorly understood. Genome-wide analyses in the mouse cerebellum revealed that the nucleosome remodeling and deacetylase (NuRD) complex deposits th...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-83253 | biostudies-arrayexpress
GenomicsTau promotes neurodegeneration through global chromatin relaxation
We performed H3K9me2-based ChIP-seq to identify regions of the Drosophila genome that are H3K9me2-depleted due to transgenic neuronal expression of human mutant tau. Examination of H3K9me2 histone methylation in 10 day old control and tau transgenic Drosophila heads.
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-53719 | biostudies-arrayexpress
GenomicsGenome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function [ChIP-Seq]
Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption o...
ORGANISM(S): Mus musculus 
2011-09-08 | E-GEOD-31951 | biostudies-arrayexpress
MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
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