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MetabolomicsViral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights
TranscriptomicsGATA-1 and heme regulate the erythroid cell transcriptome.
Alas2 gene encodes the rate-limiting enzyme in heme biosynthesis. CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital constituents of the erythroid cell transcriptome. Bypassing ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-74371 | biostudies-arrayexpress
TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 2)
The risk for colon cancer is associated with nutrition, especially high fat and low calcium diets high in red meat. Red meat contains the iron porphyrin pigment heme, which induces cytotoxicity of the colon contents and epithelial hyperproliferation. Using a mouse model, we showed that heme caused d...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27848 | biostudies-arrayexpress
TranscriptomicsStreptococcus pyogenes MGAS5005: control vs heme exposure
Transcriptional profiling of Streptococcus pyogenes MGAS5005 cells comparing control untreated GAS cells with GAS cells exposed to 4uM heme for 1.5 h Two-condition experiment, untreated vs. heme-treated MGAS5005 cells. Biological replicates: 3 control, 3 Heme-treated, independantly grown and harvest...
ORGANISM(S): Streptococcus pyogenes 
2014-09-16 | E-GEOD-61415 | biostudies-arrayexpress
TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 1)
The risk for colon cancer is associated with nutrition, especially with diets high in red meat. Red meat contains the iron porphyrin pigment heme, which induces cytotoxicity of the colon contents and epithelial hyperproliferation. Using a mouse model, we showed that heme caused damage to the colonic...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27847 | biostudies-arrayexpress
ProteomicsBacillus cereus ctaA mutant strain proteomics grown in glucose containing medium, cellular proteome
This project provides tandem mass spectrometry data of Bacillus cereus AH187 strain devoid of the heme A synthase (CtaA) protein. The mutant strain was grown on liquid MOD medium supplemented with glucose and harvested at three growth stages.
ORGANISM(S): Bacillus cereus AH187 
2022-02-22 | PXD030114 | Pride
Proteomics Ctaa mutant strain Ah187 Heme a synthase Respiratory metabolism Bacillus cereus 
ProteomicsBacillus cereus ctaA mutant strain proteomics grown in glucose containing medium, exoproteome
This project provides tandem mass spectrometry data of Bacillus cereus AH187 strain devoid of the heme A synthase (CtaA) protein. The mutant strain was grown on liquid MOD medium supplemented with glucose and harvested at three growth stages.
ORGANISM(S): Bacillus cereus AH187 
2022-02-22 | PXD030163 | Pride
Proteomics Ctaa mutant strain Ah187 Respiratory metabolism Heme a synthase Bacillus cereus Exoproteome 
TranscriptomicsTranscription profiling of C. elegans reveals heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
Hemes are essential but potentially cytotoxic cofactors that participate in critical and diverse biological processes. Although the pathway and intermediates for heme biosynthesis have been well defined, the intracellular networks which mediate heme trafficking remain unknown. Caenorhabditis e...
ORGANISM(S): Caenorhabditis elegans 
2008-10-18 | E-GEOD-8696 | biostudies-arrayexpress
UnknownHeme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli.
Not available
S-EPMC8901122 | biostudies-literature
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
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