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MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
TranscriptomicsTranscription profiling of human trophoblast cells isolated from first trimester human placentae and villous explant cultures
Invasion of cytotrophoblasts into uterine tissues is essential for placental development. To identify molecules regulating trophoblast invasion, mRNA signatures of purified villous (CTB, poor invasiveness) and extravillous (EVT, high invasiveness) trophoblasts isolated from first trimester human pla...
ORGANISM(S): Homo sapiens 
2009-01-30 | E-GEOD-9773 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of caffeic acid phenethyl ester-treated human umbilical vein endothelial cells-1
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion (I/R) injury in vivo, and this has been attributed to its ability to reduce the oxidative stress. Here we investigated the cytoprotection of CAPE against menadione (MD)-induced ...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10413 | biostudies-arrayexpress
TranscriptomicsHeme oxygenase-1 knocked down rat mesangial cells treated with hydrogen peroxide
HO-1 cells denote the cultured rat mesangial cells with heme oxygenase-1 knocked down by RNA interference (using lentiviral vector). GFP cells denote the cultured rat mesangial cells that are transfected with empty lentiviral vector containing GFP cassette. Cells are treated with hydrogen peroxide 1...
ORGANISM(S): Rattus norvegicus 
2014-01-10 | E-GEOD-53953 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of caffeic acid phenethyl ester-treated human umbilical vein endothelial cells-2
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion (I/R) injury in vivo, and this has been attributed to its ability to reduce the oxidative stress. Here we investigated the cytoprotection of CAPE against menadione (MD)-induced ...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10429 | biostudies-arrayexpress
TranscriptomicsInhibition of dendritic cell maturation and effector function
The initiation of donor derived dendritic cell (DC) adhesion and migration are one of the key events mediated by ischemia reperfusion injury (IRI) following solid organ transplantation. Recently we have been able to demonstrate that a single donor treatment with the synthetic metalloporphyrin cobalt...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-8452 | biostudies-arrayexpress
TranscriptomicsThe effect of HO-1 overexpression on microRNA transcriptome in NCI-H292 lung cancer cells
The aim was to determine the effect of heme oxygenase-1 (HO-1) overexpression on microRNA transcriptome in human non-small cell lung carcinoma cell line (NCI-H292). Since the cells of different HO-1 genotypes were used (cells are after retroviral transduction with empty vector with normal level of H...
ORGANISM(S): Homo sapiens 
2013-04-27 | E-GEOD-37779 | biostudies-arrayexpress
GenomicsControl of Renal Central Carbon Metabolism by Heme Oxygenase-1
Control of Renal Central Carbon Metabolism by Heme Oxygenase-1
PRJNA1033649 | ENA
TranscriptomicsGene expression data of endothelium exposed to heme
Sickle cell disease is characterized by hemolysis, vaso-occlusion and ischemia reperfusion injury. These events cause endothelial dysfunction and vasculopathies in multiple systems However, the lack of atherosclerotic lesions has led to the idea that there are adaptive mechanisms that protect the en...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-25014 | biostudies-arrayexpress
GenomicsIdentification of Cytoprotective Small Molecule Inducers of Heme Oxygenase-1
Identification of Cytoprotective Small Molecule Inducers of Heme Oxygenase-1
PRJNA869065 | ENA
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