Control of intracellular heme levels by extracellular scavenger proteins and intracellular heme oxygenases are essential functions during disease states with enhanced extracellular heme release. During severe hemolysis or rhabdomyolysis uncontrolled heme exposure can cause acute kidney injury and en...
Control of intracellular heme levels by extracellular scavenger proteins and intracellular heme oxygenases are essential functions during disease states with enhanced extracellular heme release. During severe hemolysis or rhabdomyolysis uncontrolled heme exposure can cause acute kidney injury and en...
Control of intracellular heme levels by extracellular scavenger proteins and intracellular heme oxygenases are essential functions during disease states with enhanced extracellular heme release. During severe hemolysis or rhabdomyolysis uncontrolled heme exposure can cause acute kidney injury and en...
Control of intracellular heme levels by extracellular scavenger proteins and intracellular heme oxygenases are essential functions during disease states with enhanced extracellular heme release. During severe hemolysis or rhabdomyolysis uncontrolled heme exposure can cause acute kidney injury and en...
Hypoglycemia is a clinical hallmark of severe malaria, the often-lethal outcome of Plasmodium falciparum infection. Yet, the underlying mechanisms driving the pathogenesis of malaria-associated hypoglycemia remain poorly understood. Here we report that labile heme, an alarmin generated as a byproduc...
This dataset derives from a comparative quantitative proteomics study designed to elucidate stage-specific molecular responses to heme-induced oxidative stress in Aedes aegypti, a major vector of dengue, Zika, and chikungunya viruses. During blood digestion in hematophagous insects, the release of f...
Mosquitoes of the genus Aedes are primary vectors of arboviruses such as dengue, Zika, and chikungunya1. Their ability to transmit pathogens is intrinsically linked to their hematophagous behavior, which presents metabolic challenges, particularly during blood digestion2,3. One major challenge is th...
