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TranscriptomicsTranscription profiling of liver from wild type and Hfe-/- mice with hereditary hemochromatosis subjected to dietary iron overload and treatment with nifedipine to reverse iron overload
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues leading to eventual organ failure. We have discovered a novel mechanism to reverse iron overload by pharmacological modulation of the dival...
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-982 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse duodenum and liver with primary (Hfe ?/? and C282Y homozygous mice) and secondary iron overload vs 129S6/SvEvTac wild type controls
We determined duodenal and liver gene response patterns in mice with primary (Hfe ?/? and C282Y homozygous mice) and secondary iron overload versus 129S6/SvEvTac wild type controls.
ORGANISM(S): Mus musculus 
2013-01-30 | E-MEXP-5 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lipopolysaccharide-induced inflammation in HFE-deficient and wild types
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is the anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron storage, resulting in low serum iron co...
ORGANISM(S): Mus musculus 
2004-03-15 | E-MEXP-95 | biostudies-arrayexpress
TranscriptomicsPaternal segmental isodisomy of centromeric region on chromosome 1 as a cause of juvenile hemochromatosis
Juvenile hemochromatosis type 2A in the studied patient was caused by a homozygous mutation c.196G>T (p.G66*) in hemojuvelin. Homozygous state for this mutation evolved through interstitial segmental isodisomy encompassing the centromeric region of chromosome 1 accompanying its paternal disomy. The ...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-50441 | biostudies-arrayexpress
UnknownRevisiting hemochromatosis: genetic vs. phenotypic manifestations.
Not available
S-EPMC8106074 | biostudies-literature
GenomicsHemochromatosis and Iron Overload Screening Study (HEIRS-BioLINCC)
Hemochromatosis and Iron Overload Screening Study (HEIRS-BioLINCC)
PRJNA1403593 | ENA
GenomicsHemochromatosis and Iron Overload Screening Study (HEIRS-BioLINCC)
Hemochromatosis and Iron Overload Screening Study (HEIRS-BioLINCC)
PRJNA1403592 | ENA
GenomicsPheripheral blood cells expression data from 18 hemochromatosis patients, with various mutations for hemochromatosis, and 6 gender and aged matched healty controls.
Pheripheral blood cells expression data from 18 hemochromatosis patients, with various mutations for hemochromatosis, and 6 gender and aged matched healty controls.
PRJNA497886 | ENA
UnknownBMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice.
Not available
S-EPMC3295242 | biostudies-literature
TranscriptomicsEffects of RGMc on BMP2 and BMP6-mediated Gene Expression in Hep3B Liver Cells
Mutations in repulsive guidance molecule c (RGMc) / hemojuvelin (HJV) cause juvenile hemochromatosis, an aggravated iron overload disorder that presents early in life. Patients with juvenile hemochromatosis, and RGMc knockout mice, have diminished expression of the key iron-regulatory peptide, hepc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-20671 | biostudies-arrayexpress
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