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ProteomicsLiver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Mild hemolysis of senescent erythrocytes occurs physiologically in the spleen resulting in Hb release, whereas pathologic erythrocyte rupture characterizes several diseases. Iron recycling from Hb and Hb detoxification have been attributed to the sequestration of Hb-haptoglobin complexes by macropha...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-12 | PXD051274 | Pride
Mouse Liver sinusoidal endothelial cells Hemoglobin clearance 
GenomicsLiver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
PRJNA1003072 | ENA
TranscriptomicsGene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance
Background and Aims: Viral clearance during acute hepatitis C virus (HCV) infection is associated with the induction of potent antiviral T-cell responses. Since dendritic cells (DC) are essential in the activation of primary T-cell responses our goal was to analyze gene expression in DC from patient...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-65123 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human stable end-stage renal disease patients reveals nocturnal hemodialysis improves erythropoietin responsiveness
Nocturnal home hemodialysis (NHD) [5 – 6 times a week, 6-8 hours per session] augments uremia clearance and is associated with an increase in hemoglobin level. We have used microarray to have a global image of the changes at the gene expression. Experiment Overall Design: Sixteen stable end-sta...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-11227 | biostudies-arrayexpress
TranscriptomicsLiver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Hemolysis of senescent erythrocytes occurs in the spleen, resulting in hemoglobin (Hb) release. Several diseases are associated with an increased risk of erythrocyte rupture. Iron recycling from Hb and Hb detoxification have been attributed to the sequestration of Hb-haptoglobin complexes by macroph...
ORGANISM(S): Mus musculus 
2025-08-01 | GSE240270 | GEO
UnknownPretransplant hemoglobin and creatinine clearance correlate with treatment-free survival after autologous stem cell transplantation for multiple myeloma.
Not available
S-EPMC7741423 | biostudies-literature
UnknownSmall-molecule inhibitor screen to identify mechanisms of sickle hemoglobin clearance by liver endothelium.
Not available
S-EPMC12143466 | biostudies-literature
UnknownMonocyte-red blood cell crosstalk supports clearance and heme metabolism in sickle cell anemia.
Not available
S-EPMC12714641 | biostudies-literature
UnknownTranspulmonary generation of cell-free hemoglobin contributes to vascular dysfunction in pulmonary arterial hypertension via dysregulated clearance mechanisms.
Not available
S-EPMC9841468 | biostudies-literature
UnknownStructural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163.
Not available
S-EPMC12273918 | biostudies-literature
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