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GenomicsIllumina Sequencing data of the influence of Insulator Proteins on chromatin
The Drosophila insulator-binding proteins (IBPs) dCTCF/Beaf32 mark the physical borders of chromosomal domains involving co-factors that participate in long-range interactions. Chromosomal borders are further enriched in specific histone modifications yet the implication of histone modifiers and nuc...
ORGANISM(S): Drosophila melanogaster 
2014-04-30 | E-GEOD-57166 | biostudies-arrayexpress
TranscriptomicsThe Histone H2B Monoubiquitination Regulatory Pathway is Required for Differentiation of Multipotent Stem Cells
Extensive changes in post-translational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However, the mechanisms controlling the changes in specific chromatin modifications and their function during differentiation remain only poorly under...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-38173 | biostudies-arrayexpress
TranscriptomicsEstrogen-dependent gene expression in human breast cancer cells relies upon proteosome-dependent monoubiquitination of histone H2B
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate e...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31118 | biostudies-arrayexpress
TranscriptomicsProteasome inhibition blocks estrogen-dependent gene transcription by decreasing histone H2B monoubiquitination in human breast cancer cells
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate est...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30931 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin changes uppon contextual fear conditioning in mice (meDIP-seq)
The ability to form memories is a prerequisite for an organism’s behavioural adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-74965 | biostudies-arrayexpress
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