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TranscriptomicsTargeting super-enhancer induced gene expression using novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
Bromodomain-containing protein 4 (BRD4) functions as an epigenetic reader and binds to so-called super-enhancer regions of driving oncogenes such as MYC in cancer. We investigated the possibility to target super-enhancer regulated genes in neuroblastoma and in MYCN amplified disease in particular. W...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-MTAB-3672 | biostudies-arrayexpress
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
GenomicsHenssen Lab Neuroblastoma Circle-seq Data
Data Access Committee EGAC00001001803
EGAC00001001803 | EGA
GenomicsHenssen Lab Neuroblastoma Circle-seq Data
Data Access Committee EGAC00001001804
EGAC00001001804 | EGA
GenomicsGenomes of Relapsing Neuroblastoma
Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often lethal when relapse occurs, but the molecular mechanisms behind this process are poorly defined. We here used whole-exome sequencing, mRNA expression, array CGH and DNA methylation analysis to holistically chara...
EGAS00001001387 | EGA
Genomicsena-DATASET-UKEssen-09-09-2015-10:54:33:815-144 - samples
In this dataset, 16 trios- primary tumor, relapse and corresponding normals- for patients with neuroblastoma are provided. For one patient, more than one relapse was available for the analyses.
EGAD00001001607 | EGA
GenomicsRelapsed and Primary Neuroblastoma DAC
Data Access Committee EGAC00001000373
EGAC00001000373 | EGA
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