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MetabolomicsMulti-omics reveals the DR5-FXR-CHPT1 axis governs hepatocyte pyroptosis via glycerophospholipid remodeling after major partial hepatectomy
Acute liver injury following major partial hepatectomy (PHx), manifesting as small-for-size syndrome (SFSS) and post-hepatectomy liver failure (PHLF), carries high mortality. However, the key mechanisms underlying irreversible remnant liver injury and cell death remain poorly understood, particularl...
2026-08-16 | MTBLS14980 | MetaboLights
TranscriptomicsMicroRNA array analysis during the regenerative peak following rat liver resection
The liver has the unique capacity to regenerate after surgical resection. However, the regulation of liver regeneration is not completely understood. We performed miRNA microarray analyses of liver tissue from Wistar rats at different time points after 70% partial hepatectomy (0, 2, 6, 12, 24, 48 ho...
ORGANISM(S): Rattus norvegicus 
2011-03-28 | E-GEOD-23696 | biostudies-arrayexpress
TranscriptomicsCharacterization of hepatic gene expression during liver regeneration in response to partial hepatectomy
This SuperSeries is composed of the following subset Series: GSE20425: Hepatic gene expression during liver regeneration in response to partial hepatectomy: early time points (0.5h,1h,2h,4h) GSE20426: Hepatic gene expression during liver regeneration in response to partial hepatectomy: late time poi...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-20427 | biostudies-arrayexpress
GenomicsGenome wide analysis of liver histone H3K9 acetylation after partial hepatectomy in glucose-treated and control mice.
We report the results of AcH3K9 ChIP-Seq on regenerating liver harvested 12 h after partial hepatectomy (PH) from mice treated with supplemental parenteral dextrose (to delay onset of PH-induced hypoglycemia) or vehicle (as control). Examination of the effect of delaying PH-induced hypoglycemia on h...
ORGANISM(S): Mus musculus 
2016-02-09 | E-GEOD-71496 | biostudies-arrayexpress
ProteomicsSILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy
Post-hepatectomy liver failure (PHLF) remains a significant risk for patients undergoing partial hepatectomy (PHx). Reliable prognostic markers and treatments to enhance liver regeneration are lacking. Plasma nanoparticles, including lipoproteins, exosomes, and extracellular vesicles (EVs), can refl...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059885 | Pride
Plasma extracellular vesicles Post-hepatectomy liver failure Proteomics 
GenomicsHepatectomy sham surgery 1h
Hepatectomy sham surgery 1h
PRJNA102679 | ENA
TranscriptomicsHepatic gene expression during liver regeneration in response to partial hepatectomy: late time points (24h, 38h, 48h)
The process of liver regeneration can be divided into a series of stages that include initial inductive or priming events through cellular mitosis. Following two-thirds liver resection, the liver undergoes the “priming” phase, in which cytokines TNF-a and IL-6 activate their respective receptors in...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-20426 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression during liver regeneration in response to partial hepatectomy: early time points (0.5h,1h,2h,4h)
The process of liver regeneration can be divided into a series of stages that include initial inductive or priming events through cellular mitosis. Following two-thirds liver resection, the liver undergoes the “priming” phase, in which cytokines TNF-a and IL-6 activate their respective receptors in...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-20425 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers at different time points after partial hepatectomy and at different time points post conception to elucidate gene expression similarities between regenerating and developing liver.
Normal adult liver is uniquely capable of renewal; and repair after injury. Whether this response; represents simple hyperplasia of various liver elements; or requires recapitulation of the genetic program of; the developing liver is not known. To study these possibilities, we examined transcription...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6998 | biostudies-arrayexpress
TranscriptomicsRNA-seq transcriptonal profiling in partial hepatectomy liver tissues in Arid1a WT and liver specific KO mice.
Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found that loss of Arid1a in the liver results in improved liver regeneration after partial hepatectomy.Genome-wide analysis showed that after hepatectomy,loss of Arid1a reduces the recruitment and activi...
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-76926 | biostudies-arrayexpress
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