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TranscriptomicsExpression data from C2C12 myotubes infected with RML prions
Prion infection in animals results in neurodegeneration and eventually death. To examine the cellular impact of Prion disease, we profiled non-proliferative fully differentiated C2C12 cells, which can replicate prions to high levels. Results suggest that accumulation of high levels of PrPSc in C2C12...
ORGANISM(S): Mus musculus 
2013-12-22 | E-GEOD-44563 | biostudies-arrayexpress
TranscriptomicsGenes expressed in age-induced mitochondrial DNA deletion mutation containing / Electron Transport abnormal cells
Muscle tissue was longitudinally characterized histologically for electron transport function by staining 1mm of quadriceps muscle at 70 micron intervals for the activities of two complexes in the mitochondrial electron transport chain, Cytochrome C Oxidase and Succinate Dehydrogenase. Unstained ser...
ORGANISM(S): Rattus norvegicus 
2013-03-01 | E-GEOD-35607 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Responses to Prion Disease in Rats
While prion infections have been extensively characterized in the laboratory mouse, little is known regarding the molecular responses to prions in other rodents. To explore these responses and make comparisons, we generated a prion disease in the laboratory rat by successive passage of mouse RML pri...
ORGANISM(S): Rattus norvegicus 
2015-09-01 | E-GEOD-63930 | biostudies-arrayexpress
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S-EPMC7255743 | biostudies-literature
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