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Herceptin (trastuzumab) is a humanized monoclonal antibody targeted to the Her2 receptor tyrosine kinase. Despite a robust response rate to Herceptin-based therapies in Her2-positive patients, resistance frequently arises within one year of the initial response. To address the mechanism of Hercept...
ORGANISM(S): Homo sapiens 
m6A modification in Herceptin resistant cells [MeRIP-Seq]
Herceptin (trastuzumab) is a humanized monoclonal antibody targeted to the Her2 receptor tyrosine kinase. Despite a robust response rate to Herceptin-based therapies in Her2-positive patients, resistance frequently arises within one year of the initial response. To address the mechanism of Herceptin...
ORGANISM(S): Homo sapiens 
2009-08-21 | GSE15043 | GEO
We report the application of specific antibodies and high-throughput sequencing technologies (methylated RNA immunoprecipitation sequencing, MeRIP-seq) for high-throughput profiling of m6A modifications in breast cancer herceptin resistant cells. We generated maps of m6A modified transcripts in BT47...
ORGANISM(S): Homo sapiens 
2024-11-18 | GSE189160 | GEO
RNA-seq analysis revealed that the cardiotoxicity caused by herceptin is due to the release of PTX3.
Gene expression profiles of Herceptin-resistant breast cancer cells
Herceptin, also known as trastuzumab, is currently approved as a targeted therapy for breast cancer and advanced gastric cancer. However, the clinical application of hercptin was limited by its severe cardiotoxicity. We found that the cardiotoxicity caused by Herceptin is due to the release of PTX3 ...
ORGANISM(S): Mus musculus 
2022-12-01 | GSE200325 | GEO
Herceptin-conjugated liposomes loaded with lipocalin-2 siRNA for the treatment of Inflammatory Breast Cancer
effect on gene expression with the treatment of dasatinib and herceptin on breast cancer cell lines
ORGANISM(S): Homo sapiens 
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