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TranscriptomicsMechanisms of CS-related A/J lung tumorigenesis
The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening system in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops tumors spontaneously. Moreover, there is a considerable...
ORGANISM(S): Mus musculus 
2014-08-29 | E-MTAB-1871 | biostudies-arrayexpress
TranscriptomicsP12365 - A/J COPD - Parenchyma
Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disorder that is the result of extended exposure of the airways to noxious stimuli, principally cigarette smoke (CS). The mechanisms through which COPD evolves are not fully understood though it is believed that the disease process includ...
ORGANISM(S): Mus musculus 
2014-05-14 | E-MTAB-1426 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling in dpa4 mutant apices compared to wild type
Experiment to detect differentially expressed genes in mutants of the predicted transcription factor DPA4 (At5g06250)
ORGANISM(S): Arabidopsis thaliana 
2012-06-15 | E-TABM-1195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain from homozygous narcoleptic dogs and their heterozygous unaffected siblings
Brain gene expression profiles of homozygous narcoleptic dogs and their heterozygous unaffected siblings
ORGANISM(S): Canis familiaris 
2007-09-27 | E-MEXP-1076 | biostudies-arrayexpress
TranscriptomicsPrenatal arsenic exposure and the epigenome: altered gene expression profiles in newborn cord blood
The Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Gómez Palacio, Mexico was recently established to better understand the impacts of prenatal exposure to inorganic arsenic (iAs). In this study, we examined a subset (n = 40) of newborn cord blood samples for microRNA (miRNA) expression...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-48354 | biostudies-arrayexpress
TranscriptomicsPrenatal arsenic exposure and the epigenome: altered miRNA expression profiles in newborn cord blood
The Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Gómez Palacio, Mexico was recently established to better understand the impacts of prenatal exposure to inorganic arsenic (iAs). In this study, we examined a subset (n = 40) of newborn cord blood samples for microRNA (miRNA) expression...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-48353 | biostudies-arrayexpress
TranscriptomicsMaternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice-the long term restoration
Early-life antibiotic exposure perturbs the intestinal microbiota, alters innate intestinal immunity, and accelerates type 1 diabetes development in the NOD mouse model. Here we found that maternal cecal microbiota transfer (CMT) to NOD mice with early-life antibiotic perturbation partially rescued ...
ORGANISM(S): Mus musculus 
2021-09-02 | E-MTAB-9982 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms of cigarette smoke-induced lung emphysema
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disorder primarily induced by cigarette smoking, and characterized by persistent airflow limitation. The mouse represents an important model for studying COPD pathologies such as lung emphysema. In this respect, a number of mechanis...
ORGANISM(S): Mus musculus 
2014-11-28 | E-MTAB-2756 | biostudies-arrayexpress
TranscriptomicsComparison of stimulatory and inhibitory dendritic cell subsets reveals new role of DC in granulomatous infection
Myeloid dendritic cells (DC) and macrophages play an important role in pathogen sensing and antimicrobial defense. Recently we demonstrated that infection of human DC with intracellular bacterium Listeria monocytogenes (L.monocytogenes) leads to the induction of the immunoinhibitory enzyme indoleami...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-9946 | biostudies-arrayexpress
TranscriptomicsSirolimus induced phosphaturia
Introduction: The kidney is the major arbiter of extracellular phosphate homeostasis. The vast majority of glomerular filtrated phosphate is reabsorbed in the proximal tubule. Posttransplant phosphaturia is common and aggravated by sirolimus immunosuppression. The cause of sirolimus induced phosphat...
ORGANISM(S): Rattus norvegicus 
2012-09-24 | E-GEOD-35048 | biostudies-arrayexpress
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