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ProteomicsReduviid venom composition to inform venom evolution and evolution of blood-feeding
We found that assassin bugs from the earliest-diverging subfamily of higher Reduviidae (Peiratinae), as well as a subfamily closely related to Triatominae (Stenopodainae) have venom that is highly similar in composition to that produced by previously examined reduviids from Harpactorinae and Reduvii...
ORGANISM(S): Oncocephalus Ectomocoris 
2024-07-30 | PXD050854 | Pride
Reduviidae  venom  molecular evolution  anticoagulant 
UnknownSystematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial.

Background

Fluid boluses are administered to septic shock patients with the purpose of increasing cardiac output as a means to restore tissue perfusion. Unfortunately, fluid therapy has a narrow therapeutic index, and therefore, several approaches to increase safety have been proposed. Fluid...
S-EPMC6979284 | biostudies-literature
UnknownAddressing language challenges in bilingual neuropsychological assessments at the South Texas Alzheimer's Disease Research Center (ADRC).

Introduction

Neuropsychological assessment of bilingual (English/Spanish) individuals presents challenges that can impact test validity. Language proficiency influences cognitive performance, yet clear guidelines for determining the appropriate test language are lacking. We describe our expe...
S-EPMC12531422 | biostudies-literature
UnknownEvaluation of prognostic factors in patients with high-risk classical Hodgkin lymphoma undergoing autologous transplantation.

Abstract

There are limited data assessing the risk scores for primary treatment failure (PTF) in patients with classical Hodgkin lymphoma (cHL; PTF-cHL) undergoing autologous hematopoietic cell transplantation (auto-HCT). ECLIPSE (Evaluation of Classical Hodgkin Lymphoma patients wIth Primar...
S-EPMC11532746 | biostudies-literature
UnknownSignature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals.

Background

White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in particular hypertension, are associated with WMH in particular locations of the white matter. ...
S-EPMC12447828 | biostudies-literature
UnknownDemographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.

Background

Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker...
S-EPMC11615965 | biostudies-literature
UnknownValidation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS.

Objective

To identify preferred neurofilament assays and clinically validate serum neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development.

Methods

S-EPMC7371380 | biostudies-literature
UnknownObservation of a mixed close-packed structure in superionic water.
The study of superionic (SI) water has been a highly active research area since its theoretical prediction. Despite significant experimental and computational efforts, its melting curve and the stability of different oxygen lattices remain debated, impacting our understanding of SI ice's peculiar tr...
S-EPMC12796318 | biostudies-literature
UnknownRNA splicing programs define tissue compartments and cell types at single-cell resolution.
The extent splicing is regulated at single-cell resolution has remained controversial due to both available data and methods to interpret it. We apply the SpliZ, a new statistical approach, to detect cell-type-specific splicing in >110K cells from 12 human tissues. Using 10X Chromium data for discov...
S-EPMC8563012 | biostudies-literature
UnknownBiodiversity inventories in high gear: DNA barcoding facilitates a rapid biotic survey of a temperate nature reserve.

Background

Comprehensive biotic surveys, or 'all taxon biodiversity inventories' (ATBI), have traditionally been limited in scale or scope due to the complications surrounding specimen sorting and species identification. To circumvent these issues, several ATBI projects have successfully int...
S-EPMC4568406 | biostudies-literature
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