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TranscriptomicsTranscription profiling of human multiple myeloma cell lines treated with EZH2 inhibitor E7438 and DMSO controls
We used a total of 10 human multiple myeloma cell lines for the study (KMS-20, KMS-28BM, MOLP-8, RPMI-8226, U-266, KMS-11, KMS-12-PE, KMS-34, LP-1 and NCI-H929). Cells (2 x 105 per well) were seeded into six-well culture plates in the appropriate culture media 24 h before treatment. Five replicate w...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-MTAB-3540 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA methylation changes in monocytes to osteoclast differentiation
Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system involving differentiation and massive cell fusion. Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in seve...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-46648 | biostudies-arrayexpress
TranscriptomicsUse of the B cell transcription program results in hypomethylation and overexpression of key genes in EBV-mediated conversion of resting to proliferative B cells
We investigated the effects of experimental EBV infection of B cells on DNA methylation profiles by using high-throughput analysis. Remarkably, we observed hypomethylation of around 250 genes, but no hypermethylation. Hypomethylation did not occur at repetitive sequences, consistent with the absence...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-41957 | biostudies-arrayexpress
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