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TranscriptomicsRNA seq of a pancreatic cancer patient-derived xenografts treated with Vehicle or Gemcitabine/Paclitaxel in mouse
Identification of regulated genes in Patient-derived xenografts from pancreatic cancer
ORGANISM(S): Homo sapiens 
2023-03-21 | E-MTAB-11739 | biostudies-arrayexpress
TranscriptomicsleChRO-seq for 2 pancreatic cancer patient-derived xenografts treated with Vehicle or Gemcitabine/Paclitaxel in mouse
Evaluation of nascent RNA in PDX
ORGANISM(S): Homo sapiens 
2023-03-21 | E-MTAB-11740 | biostudies-arrayexpress
TranscriptomicsLoss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC indu...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-68808 | biostudies-arrayexpress
TranscriptomicsAntithetical NFATc1-Sox2 and p53-miR-200 signalling networks governs pancreatic cancer cell plasticity and tumour progression
Pancreatic ductal adenocarcinoma (PDAC) cells undergo epithelial mesenchymal transdifferentiation (EMT) in adaption to environmental cues, including inflammation, a process that combines tumour cell dedifferentiation with dissemination and acquisition of stemness features. However, the mechanisms co...
ORGANISM(S): Mus musculus 
2015-02-10 | E-MTAB-2324 | biostudies-arrayexpress
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