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MetabolomicsUnraveling the Heterogeneity of Hyperuricemia Using Untargeted Metabolomics and Statistical Modeling

Background. Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specific biomarkers and precise therapeutic targets ...

2025-10-05 | MTBLS13094 | MetaboLights
MetabolomicsRespectM revealed metabolic heterogeneity powers deep learning for reshaping the DBTL cycle

Synthetic biology, relying on Design-Build-Test-Learn (DBTL) cycle, aims to solve medicine, manufacturing and agriculture problems. However, the DBTL cycle’s Learn (L) step lacks predictive power for the behavior of biological systems, resulting from the incompatibility between sparse testing dat...

2023-06-29 | MTBLS3830 | MetaboLights
MetabolomicsMetabolic heterogeneity in Glioblastoma
Not available
ORGANISM(S): Homo sapiens 
ST000248 | MetabolomicsWorkbench
MetabolomicsCell-to-cell heterogeneity drives host-virus coexistence in a bloom-forming alga

Algal blooms drive global biogeochemical cycles of key nutrients in the oceans and serve as hotspots for biological interactions. The massive spring blooms of the cosmopolitan coccolithophore Emiliania huxleyi (E. huxleyi) are often infected by the lytic Emiliania huxleyi

2024-01-04 | MTBLS1956 | MetaboLights
MetabolomicsSingle-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis

Raw data of both bulk and single-cell metabolomics. It includes all MS, LC-MS and LC-MS/MS raw data associated with the article 'Single-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis'.

2026-02-14 | MTBLS13900 | MetaboLights
MetabolomicsSingle-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

Macrophage-derived foam cell plays a pivotal role in the plaque formation and rupture during the progression of atherosclerosis. Foam cells are destined to divergent cell fate and functions in response to external stimuli based on their internal states, which however is hidden in the traditional ...

2023-09-08 | MTBLS6366 | MetaboLights
MetabolomicsRhizosphere microorganism and leaf metabolomics explain the adaption and habitat heterogeneity of two Zoysia species from the Yellow River Delta
This study investigates the metabolic responses of two Zoysia species (Z. macrostachya and Z. sinica) adapted to distinct microhabitats in the Yellow River Delta. Leaf samples were collected from natural populations growing under different saline-alkaline conditions. Untargeted metabolomics was perf...
2026-07-13 | MTBLS15027 | MetaboLights
MetabolomicsA non-dividing population with high pyruvate dehydrogenase kinase activity drives metabolic heterogeneity and tumorigenesis in the intestine
Not available
ORGANISM(S): Mus musculus 
ST002072 | MetabolomicsWorkbench
ProteomicsQuantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics
We combined the Single-probe single cell MS(SCMS) experimental technique with a bioinformatics software package, SinCHet-MS (Single Cell Heterogeneity for Mass Spectrometry), to characterize changes of tumor heterogeneity, quantify cell subpopulations, and prioritize the metabolite biomarkers of eac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-15 | MSV000092178 | MassIVE
TranscriptomicsGenetic Heterogeneity of DLBCL
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome and exome sequencing, we characterized the gen...
ORGANISM(S): Homo sapiens 
2013-01-23 | E-GEOD-43606 | biostudies-arrayexpress
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