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TranscriptomicsGATA-1 and heme regulate the erythroid cell transcriptome.
Alas2 gene encodes the rate-limiting enzyme in heme biosynthesis. CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital constituents of the erythroid cell transcriptome. Bypassing ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-74371 | biostudies-arrayexpress
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