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TranscriptomicsEvidence that variation in adult body size among mammalian species is achieved by modulating the pace of a growth-regulating genetic program
Body size varies enormously among mammalian species. In small mammals, body growth is typically suppressed rapidly, within weeks, whereas in large mammals, growth is suppressed slowly, over years, allowing for a greater adult size. We recently reported evidence that body growth suppression in rodent...
ORGANISM(S): Ovis aries 
2014-05-19 | E-GEOD-48916 | biostudies-arrayexpress
TranscriptomicsMouse Spontaneous C3H/HeJ AA Skin
Our goal was to develop a transcriptomic description of affected alopecic skin from aged C3H/HeJ mice. Affected skin from 3 mice was compared to skin from similarly aged but unaffected C3H/HeJ mice. 3 biological replicates from 3 separate affected mice compared with 3 biological replicate controls ...
ORGANISM(S): Mus musculus 
2014-08-17 | E-GEOD-45513 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by array of human paired adipose tissue (subcutaneous and omentum) before and after gastric-bypass and weight loss
Objective: Adipose tissue plays a key role in obesity related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in inter-cellular and inter-organ communication. We hypothesised that miRNA levels in adipose tissue would change after gastric bypass surgery and that this wo...
ORGANISM(S): Homo sapiens 
2019-12-16 | E-MTAB-8594 | biostudies-arrayexpress
TranscriptomicsHuman Alopecia Areata Skin Profiling
Our goal was to develop a transcriptomic description of affected alopecic scalp skin from patients with alopecia areata. 5 biological replicates of skin samples from 5 separate AA patients compared with 5 similar scalp samples from healthy control patients
ORGANISM(S): Homo sapiens 
2014-08-17 | E-GEOD-45512 | biostudies-arrayexpress
TranscriptomicsExpression Quantitative Trait Loci and their relationship with lipid deposition in gluteus medius muscle of Duroc pigs
In the last 20 years, there has been significant research towards defining the genetic basis of lipid metabolism and meat quality related traits in pigs. Nowadays, the study of the transcriptome and its regulatory mechanisms allows going far beyond in the genetic dissection of these complex traits. ...
ORGANISM(S): Sus scrofa 
2010-12-16 | E-GEOD-26091 | biostudies-arrayexpress
Transcriptomics24h time-course microarray study of SW480 and SW620 cells
A 24h time-course array study was performed to analyse the different circadian phenotypes of SW480 and SW620 cells, a cell line from a primary tumor and a metastatic cell line from the same patient. Samples were taken every three hours for a period of 24h so that 9 time-points could be analysed for ...
ORGANISM(S): Homo sapiens 
2018-07-23 | E-MTAB-5876 | biostudies-arrayexpress
Transcriptomics24h time-course microarray study of HD-MY-Z and LCL-H0 cells
A 24h time-course array study was performed to analyse the different circadian phenotypes of LCL-H0 and HD-MY-Z cells, a cell line from B lymphoblastoid cells and a Hodgkin lymphoma cell line. Samples were taken every three hours for a period of 24h so that 9 time-points could be analysed for each c...
ORGANISM(S): Homo sapiens 
2019-03-11 | E-MTAB-6400 | biostudies-arrayexpress
TranscriptomicsPorcine intramuscular fat content and composition are regulated by quantitative trait loci with muscle-specific effects
Intramuscular fat (IMF) storage is a biological process with strong impact on nutritional and technological properties of meat, and also with relevant consequences on human health. The genetic architecture of IMF content and composition phenotypes has been thoroughly studied in pigs through the iden...
ORGANISM(S): Sus scrofa 
2010-12-01 | E-GEOD-25708 | biostudies-arrayexpress
TranscriptomicsPrevention of Mouse AA with IL-15 pathway inhibitors
Our goal was to identify gene expression patterns that correlated with prevention of autoimmune alopecia in C3H/HeJ mice following alopecic graft transplantation skin from 3-5 mice were taken at 5/6 weeks and 12/13 weeks of drug administration following grafting; mice were treated with ruxolitinib (...
ORGANISM(S): Mus musculus 
2014-08-17 | E-GEOD-45551 | biostudies-arrayexpress
TranscriptomicsTreatment of established mouse AA with topical JAK inhibitors
Our goal was to identify gene expression patterns that correlated with treatment of established autoimmune alopecia in C3H/HeJ mice following alopecic graft transplantation skin from 3 mice were taken at 6, 12 and, in some cases, 24 weeks of topical drug administration following grafting; mice were ...
ORGANISM(S): Mus musculus 
2014-08-17 | E-GEOD-45514 | biostudies-arrayexpress
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