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TranscriptomicsDiabetic lung
Effect of type 1 diabetes (induced by streptozotocin 60 mg/kg) on lung gene expression. Wistar rats, male. At age 8 weeks control rats got IP buffer, diabetic rats got streptozotocin. At age 12 weeks animals were anesthetized and lungs removed. RNA was extracted with Trizol, and gene expression ...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-15900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Bordetella bronchiseptica strains 253 and RB50 to investigate adenylate cyclase toxin (ACT) expression
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B. ...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1203 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Bordetella bronchiseptica strains 253 and RB50 to investigate the cya adenylate cyclase toxin (ACT) operon
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1205 | biostudies-arrayexpress
TranscriptomicsHuman colon epithelial treated with Clostridium difficile Toxins A and B
Toxin A and B from Clostridium difficile are the primary virulence factors in Clostridium difficile disease. The changes in gene transcription of human colon epithelial cells were investigated in vitro in order to better understand the many effects of both toxins. HCT-8 cells were treated with 100 n...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29008 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of MCF-7 cells expressing or not MMP-14 (MT1-MMP) growing in monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (VEC) or human MMP-14 cDNA (MT1) in monolayer growth conditions. MCF-7 cel...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-64320 | biostudies-arrayexpress
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