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TranscriptomicsEffects of selection on residual feed intake and diet on gene expression in pig subcutaneous adipose tissue
Transcriptional profiling in subcutaneous adipose tissue of 48 pigs aged (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy sour...
ORGANISM(S): Sus scrofa 
2016-07-01 | E-GEOD-70836 | biostudies-arrayexpress
TranscriptomicsEffects of selection on residual feed intake and diet on gene expression in pig perirenal adipose tissue
Transcriptional profiling in peritoneal adipose tissue of 48 pigs (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy source and ...
ORGANISM(S): Sus scrofa 
2016-07-01 | E-GEOD-70837 | biostudies-arrayexpress
TranscriptomicsEffect of selection on residual feed intake and diet on gene expression in whole blood of pig
Transcriptional profiling in the whole blood of 48 pigs (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy source and nutrients:...
ORGANISM(S): Sus scrofa 
2016-07-01 | E-GEOD-70838 | biostudies-arrayexpress
TranscriptomicsGermfree C57BL/6J mice are resistant to high fat diet-induced insulin resistance and have altered cholesterol metabolism
Germfree (GF) mice have been used as a model to study the contribution of the intestinal microbiota to metabolic energy balance of the host. Despite a wealth of knowledge accumulated since the 1940’s, the response of GF mice to a high fat diet is largely unknown. In the present study, we compared th...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-19038 | biostudies-arrayexpress
TranscriptomicsSaturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine
We studied the effect of dietary fat type, varying in polyunsaturated/saturated fatty acid ratio's (P/S) on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1) or safflower oil (HF-SO; P/S 7.8) ...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-18586 | biostudies-arrayexpress
TranscriptomicsPersistent chromatin modifications induced by high fat diet
Obesity is a highly heritable complex disease that results from the interaction of multiple genetic and environmental factors. Formerly obese individuals are susceptible to metabolic disorders later in life, even after lifestyle changes are made to mitigate the obese state. This is reminiscent of th...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-75984 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse liver treated with metformin
Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes. We examined the effects of metformin, commonly used to treat patients with type 2 diabetes, on liver pathology in a non-diabetic NASH mouse model. Eight-week-old C57...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-35961 | biostudies-arrayexpress
TranscriptomicsShort-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice
The prevalence of the metabolic syndrome (MS) is rapidly increasing all over the world. Consequently, there is an urgent need for more effective intervention strategies. Both animal and human studies indicate that lipid oversupply to skeletal muscle can result in insulin resistance which is one of t...
ORGANISM(S): Mus musculus 
2007-11-30 | E-GEOD-8524 | biostudies-arrayexpress
TranscriptomicsDiet-induced chromatin remodeling in mice livers
The tissue-specific packaging of the genome into the nucleus through chromatin is fundamentally involved in gene regulation, and aberrant modifications to chromatin are a hallmark of many diseases. We show here that a high fat (HF) diet leads to substantial chromatin remodeling in the livers of C57B...
ORGANISM(S): Mus musculus 
2014-07-17 | E-GEOD-55581 | biostudies-arrayexpress
GenomicsMice livers: high fat diet versus high fat diet (HF) supplemented with pirfenidone (HFP)
Mice livers: high fat diet versus high fat diet (HF) supplemented with pirfenidone (HFP)
PRJNA1149047 | ENA
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