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TranscriptomicsscRNA-seq of aortic arches from smooth muscle cell–specific Hif1a knockout and control mice with atherosclerosis
Smooth muscle cells (SMCs) undergo phenotypic switching during atherosclerosis and give rise to a large fraction of plaque cells. To investigate the role of hypoxia-inducible factor 1α (HIF1α) signaling in SMC behaviour during atherogenesis, we used mice in which Hif1a is conditionally deleted in li...
ORGANISM(S): Mus musculus 
2026-06-21 | E-MTAB-17142 | biostudies-arrayexpress
TranscriptomicsSIRT3 opposes metabolic reprogramming of cancer cells through HIF1a destabilization
Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates and redox potential required for the generation of biomass. Here, we show that the mitochondria...
ORGANISM(S): Mus musculus 
2011-03-15 | E-GEOD-27309 | biostudies-arrayexpress
GenomicsRescue of HIF1A protein level by E3-ligase KO
Rescue of HIF1A protein level by E3-ligase KO
PRJNA949239 | ENA
TranscriptomicsA genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanistically enforce and maintain the naïve T cell fate. Here we show that Id2 and Id3 suppressed the development and expansion o...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64779 | biostudies-arrayexpress
UnknownAblation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
Not available
S-EPMC10240988 | biostudies-literature
UnknownGranulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/HIF1a axis.
Not available
S-EPMC11014666 | biostudies-literature
UnknownLactate exacerbates lung damage induced by nanomicroplastic through the gut microbiota-HIF1a/PTBP1 pathway.
Not available
S-EPMC10766629 | biostudies-literature
GenomicsSingle cell RNA sequencing of intestinal NKp46+ innate lymphoid cells (ILCs) from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Single cell RNA sequencing of intestinal NKp46+ innate lymphoid cells (ILCs) from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
PRJEB49270 | ENA
UnknownThe WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders.
Not available
S-EPMC8955937 | biostudies-literature
UnknownRestricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer.
Not available
S-EPMC12582411 | biostudies-literature
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