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MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
UnknownCell-type specific effects of the long non-coding RNA HIF1A-AS3 on HIF1A expression in kidney cells.
Not available
S-EPMC12310967 | biostudies-literature
TranscriptomicsKaiso is a novel TAZ-interaction partner that promotes hepatic stellate cell activation and regulates the downstream lncRNA HIF1A-AS3
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), are key regulators of hepatic stellate cell (HSC) activation and liver fibrosis. While the canonical YAP/TAZ-TEAD axis is well-characterized, non-canonical interaction partners and downstream long non-coding R...
ORGANISM(S): Homo sapiens 
2026-09-14 | GSE345280 | GEO
GenomicsKaiso is a novel TAZ-interaction partner that promotes hepatic stellate cell activation and regulates the downstream lncRNA HIF1A-AS3
Kaiso is a novel TAZ-interaction partner that promotes hepatic stellate cell activation and regulates the downstream lncRNA HIF1A-AS3
PRJNA1519744 | ENA
TranscriptomicsChronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression
Chronic psychological stress is closely linked to malignant disorders, with novel modulators potentially mitigating tumor progression by regulating interactions between neoplastic cells and immune cells. This study identified lncRNA HIF1A-AS3 as a key driver of stress-induced lung cancer progression...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE287196 | GEO
TranscriptomicsChronic stress stimulated HIF-AS3/HIF-1α loop in neoplastic cells and promoted lung cancer progression through macrophage inactivation [A549_xenograft]
Chronic psychological stress is closely linked to malignant disorders, with novel modulators potentially mitigating tumor progression by regulating interactions between neoplastic cells and immune cells. This study identified lncRNA HIF1A-AS3 as a key driver of stress-induced lung cancer progression...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE287282 | GEO
TranscriptomicsChronic stress stimulated HIF-AS3/HIF-1α loop in neoplastic cells and promoted lung cancer progression through macrophage inactivation [A549 and H1299]
Chronic psychological stress is closely linked to malignant disorders, with novel modulators potentially mitigating tumor progression by regulating interactions between neoplastic cells and immune cells. This study identified lncRNA HIF1A-AS3 as a key driver of stress-induced lung cancer progression...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE287281 | GEO
GenomicsChronic stress stimulated HIF-AS3/HIF-1α loop in neoplastic cells and promoted lung cancer progression through macrophage inactivation [A549_xenograft]
Chronic stress stimulated HIF-AS3/HIF-1α loop in neoplastic cells and promoted lung cancer progression through macrophage inactivation [A549_xenograft]
PRJNA1212021 | ENA
GenomicsChronic stress stimulated HIF-AS3/HIF-1α loop in neoplastic cells and promoted lung cancer progression through macrophage inactivation [A549 and H1299]
Chronic stress stimulated HIF-AS3/HIF-1α loop in neoplastic cells and promoted lung cancer progression through macrophage inactivation [A549 and H1299]
PRJNA1212023 | ENA
GenomicsChronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression
Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression
PRJNA1211583 | ENA
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