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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
UnknownRegulation of human cytidine triphosphate synthetase 2 by phosphorylation.
Not available
S-EPMC2962471 | biostudies-literature
TranscriptomicsRNA-seq comparison of gene expression in enteroids derived of fresh or frozen human intestinal biopsies
Background & Aims Patient-derived gastrointestinal organoids are powerful tools for studying human physiology and disease. However, generating organoids requires prompt isolation and culture of fresh tissue, which is labor and time intensive, placing restraints on basic and clinical research. For ex...
ORGANISM(S): Homo sapiens 
2018-06-30 | E-MTAB-6516 | biostudies-arrayexpress
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
ProteomicsChemoproteomic profiling of Plasmodium falciparum Hsp90 inhibition reveals functional link to DNA replication pathways
Heat shock protein 90 (Hsp90) plays a critical role in maintaining the proteostasis of Plasmodium falciparum, the most lethal malaria parasite. Although PfHsp90 is recognized as a promising antimalarial target, its interactome and the global proteomic remodeling induced by its inhibition remain poor...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2026-08-28 | PXD079493 | Pride
Heat shock protein 90  hsp90  plasmodium  chemoproteomics  synergy 
UnknownA multi-centre, participant-blinded, randomized, 3-year study to compare the efficacy of Virtual Surgical Planning (VSP) to Freehand Surgery (FHS) on bony union and quality of life outcomes for mandibular reconstruction with fibular and scapular free flaps: study protocol for a randomized phase II/III trial.
Not available
S-EPMC11866805 | biostudies-literature
TranscriptomicsTranscriptional responses of sympathetic neurons during BMP-induced primary dendritogenesis
The objective of this study was to identify genes that are differentially regulated in cultured sympathetic neurons during BMP-induced dendritic growth and to determine the temporal expression patterns of these genes. We determined that inhibiting transcription within the first 24 hours after adding...
ORGANISM(S): Rattus norvegicus 
2011-06-30 | E-GEOD-28150 | biostudies-arrayexpress
UnknownLack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
Not available
S-EPMC3636768 | biostudies-literature
TranscriptomicsBulk RNA-seq of Adult and Fetal Enteroids (Control or Treated with DBZ)
Bulk RNA sequencing data of both adult and fetal enteroid lines cultured for 1 or 3 days. Conditions include enteroids grown in control basal media and basal media with the notch inhibitor DBZ added.
ORGANISM(S): Homo sapiens 
2022-04-08 | E-MTAB-11619 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis mutant for abi1, aba1, max4, axr1, AtMYB50 or AtMYB61
Plants that exhibit secondary growth, such as trees, are a prominent feature of terrestrial ecosystems. Furthermore, secondary growth itself, particularly wood, has huge economic value. Despite the importance of secondary growth from both basic and applied science perspectives, little is known abou...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6151 | biostudies-arrayexpress
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