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TranscriptomicsTranscription profiling of human psoriasis patient matched lesion and normal tissue vs. normal controls - type i interferon: potential therapeutic target for psoriasis?
We observed robust overexpression of type I interferon (IFN)-inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dend...
ORGANISM(S): Homo sapiens 
2009-03-01 | E-GEOD-14905 | biostudies-arrayexpress
TranscriptomicsSuppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis
Type I IFNs are implicated in the pathophysiology of systemic sclerosis (SSc). Recently, a Phase I open-label trial was conducted with an anti-IFNAR1 receptor antibody (anifrolumab) in adult SSc patients. In this study, we aim to assess the downstream effects of anifrolumab and elucidate the role of...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-65336 | biostudies-arrayexpress
TranscriptomicsThe RNAseq of 79 small cell lung cancer (sclc) and 7 normal control
Even though small cell lung cancer (SCLC) has entered the age of broad genomic analysis, platinum-based chemotherapy remains the standard care for SCLC. Topotecan is the only approved agent for recurrent or progressive SCLC (1). In the absence of well-defined genomic biomarkers, clinical efficacy s...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-60052 | biostudies-arrayexpress
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