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MetabolomicsMetabolomic Fingerprinting of Human High Grade Serous Ovarian Carcinoma Cell Lines
Not available
ORGANISM(S): Homo sapiens 
ST001983 | MetabolomicsWorkbench
MetabolomicsTime-Resolved Metabolomics of a Mouse Model of Ovarian High-Grade Serous Carcinoma (LC-MS)
Not available
ORGANISM(S): Mus musculus 
ST002067 | MetabolomicsWorkbench
TranscriptomicsmiRNA profiling in high-grade serous ovarian carcinoma
In this study, we performed miRNA profiles analysis of high-grade serous ovarian carcinoma compared to normal fallopian tube fimbria using microarray (Exiqon, Denmark) to evaluate their potential role in the pathogenesis of uterine leiomyoma. miRNA profiling analysis of the 10 samples including 5 h...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-61485 | biostudies-arrayexpress
TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human non-malignant fallopian tube epithelium and high grade serous carcinoma.
The purpose of this study was to identify molecular alterations potentially involved in predisposition to adnexal serous carcinoma (SerCa) in the non-malignant fallopian tube epithelium (FTE) of BRCA1/2-mutation carriers, given recent evidence implicating the distal FTE as a common source for SerC...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10971 | biostudies-arrayexpress
TranscriptomicsNeoadjuvant chemotherapy modulates T cell responses in high-grade serous ovarian cancer metastases
Our data suggest that neoadjuvant chemotherapy enhances anti-cancer responses of T cells in peritoneal metastases of patients with high-grade serous ovarian cancer but does not decrease levels of immune checkpoint molecules, providing a rationale for sequential chemo-immunotherapy. tRNA was isolated...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-71340 | biostudies-arrayexpress
TranscriptomicsProfiles of genomic instability in high-grade serous ovarian cancer (HGSC) predict treatment outcome
Profiling of loss of heterozygosity (LOH) in HGSC, subcrouping HGSC by LOH-based clustering and comparing to the LOH profiles of triple-negative breast cancer [previously submitted; GSE19594]. Study for the correlation of LOH burdern and LOH-based subgroups to clinical response to platinum-based ch...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-39130 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human LMP ovarian tumors and low-grade ovarian carcinomas to identify genes which dffer from high-grade ovarian carcinomas - PAX2: a potential biomarker for low malignant potential ovarian tumors and low-grade serous ovarian carcinomas
Objective: Ovarian tumors of low-malignant potential (LMP) and low-grade serous ovarian carcinomas are thought to represent different stages on a tumorigenic continuum and to develop along pathways distinct from that of high-grade serous ovarian carcinoma. Past studies have utilized gene expression...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-14001 | biostudies-arrayexpress
TranscriptomicsDevelopment and Independent Validation of a Molecular Subtype in High Grade Serous Ovarian Cancer using Formalin Fixed Paraffin Embedded Tissue, Training set
High Grade Serous Ovarian Cancer (HGSOC) is a histopathological diagnosis and may represent multiple diseases at a molecular level. We investigated whether distinct molecular subgroups may influence treatment choice. The accompanying validation set of data has also been deposited in ArrayExpress und...
ORGANISM(S): Homo sapiens 
2020-12-21 | E-MTAB-2562 | biostudies-arrayexpress
TranscriptomicsMevalonate pathway antagonist inhibits proliferation of serous tubal intraepithelial carcinoma and ovarian carcinoma in mouse models.
Statins are among the most frequently prescribed drugs because of their efficacy and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to inhibit the proliferative activity of cancer cells, especially those with *TP53* mutations. Since *TP53* mutations occur in ...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-68986 | biostudies-arrayexpress
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