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TranscriptomicsHMGA1: A master regulator of tumor progression in triple-negative breast cancer cells
Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process are poorly understood. Here, we show for the first time that the high mobility group A1 (HMGA1) gene drives metastatic progression in triple ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-45483 | biostudies-arrayexpress
TranscriptomicsPivotal role of HMGA1 gene signature in highly metastatic breast cancer
Analysis of MDA-MB-231 breast cancer cells depleted for High Mobility Group A1 (HMGA1) using siRNA. HMGA1 is involved in invasion and metastasis in breast cancer cells. Results identify the specific transcriptional program induced by HMGA1 in highly metastatic breast cancer cells. MDA-MB-231 cells w...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-35525 | biostudies-arrayexpress
ProteomicsProteomic analysis of HMGA1-silencing
HMGA1 is a well-established oncogene and is a master regulator in breast cancer cells controlling the shift from a non-tumorigenic epithelial-like phenotype towards a highly aggressive mesenchymal-like one. In this work we compared HMGA1-silenced versus control MDA-MB-231 by means of a label free sh...
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD002032 | Pride
Label free proteomics High mobility protein hmga1 Filter aided sample preparation Breast cancer 
GenomicsHigh mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity
High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity
PRJNA1097547 | ENA
TranscriptomicsHigh mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity
Esophageal squamous cell carcinoma (ESCC) is a common and aggressive cancer with limited responses to immunotherapy. High mobility group A1 (HMGA1), a chromatin remodeling protein, plays a key role in tumor progression, but its impact on anti-tumor immunity in ESCC remains unclear. Here we show that...
ORGANISM(S): Homo sapiens 
2025-03-05 | GSE263439 | GEO
UnknownHigh mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer.
Not available
S-EPMC9301627 | biostudies-literature
UnknownHigh mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis.
Not available
S-EPMC11568219 | biostudies-literature
UnknownHigh mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.
Not available
S-EPMC8887475 | biostudies-literature
TranscriptomicsHMGA1 and FOXM1 synergistically regulate a common gene network modulating angiogenesis in breast cancer
One of the factors involved in TNBC aggressiveness is HMGA1, a member of non-histone chromatin proteins. The High mobility group A1 is an architectural transcription factor which, by altering chromatin structure and interacting with transcription factors, can regulate the transcription of several ge...
ORGANISM(S): Homo sapiens 
2019-07-29 | GSE129915 | GEO
TranscriptomicsHMGA1 causes a global shift in chromatin architecture linked to transcriptional changes [scRNA-Seq]
High Mobility Group A1 (HMGA1) is an architectural chromatin-binding protein that regulates gene expression in various biological contexts, including differentiation and cancer. While previous studies show that HMGA1 acts by binding specific gene promoters or by contributing to the enhanceosome, its...
ORGANISM(S): Homo sapiens 
2024-07-08 | GSE245807 | GEO
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