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MetabolomicsDysregulated high-density lipoprotein and low-density lipoprotein subfractions increase metabolic dysfunction-associated steatotic liver disease risk: A study of patients across body mass index categories

Background: To investigate biomarker differences among patients with metabolic dysfunction-associated steatotic liver disease (MASLD) across body mass index (BMI) types, we analyzed clinical data from 2,013 subjects and serum samples from 402 patients. The clinical characteristic...

2026-02-05 | MTBLS13821 | MetaboLights
ProteomicsProteomics of high density lipoprotein subfractions in type 1 diabetes mellitus and controls
Toyoshima MTK. Proteomics and functionality of high-density lipoprotein subfractions and subclinical cardiovascular disease in type 1 diabetes mellitus. Faculdade de Medicina, Universidade de Sao Paulo 2021.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-13 | MSV000087986 | MassIVE
MetabolomicsDistinct Metabolomic and Lipoprotein signatures in Gall Bladder Cancer patients of Black African ancestry

Gallbladder cancer (GBC) is the most common biliary tract malignancy and is often diagnosed at advanced stages, partly due to the absence of reliable biomarkers and limited understanding of its biology in African populations. This study aimed to characterize the metabolomic and lipoprotein profil...

2025-09-05 | MTBLS12944 | MetaboLights
MetabolomicsComparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an...

2026-02-02 | MTBLS13820 | MetaboLights
TranscriptomicsMicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (HG-U133 2.0)
Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that human high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Highly-purified fracti...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-25311 | biostudies-arrayexpress
TranscriptomicsIn vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei
The host range of African trypanosomes is influenced by innate protective molecules in the blood of primates. A subfraction of human high-density lipoprotein (HDL) containing apolipoprotein A-I, apolipoprotein L-I, and haptoglobin-related protein is toxic to Trypanosoma brucei brucei but not the hum...
ORGANISM(S): Trypanosoma brucei brucei 
2007-07-04 | E-GEOD-8369 | biostudies-arrayexpress
MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
ProteomicsSecreted dengue virus NS1 is predominantly dimeric and in complex with high-density lipoprotein
Cross-linking mass spectrometry was performed on 1) wild-type secreted dengue virus (DENV2) sNS1 protein with bovine ApoA1 (major component of high-density lipoprotein) and 2) mutant (T164S) sNS1 protein with bovine ApoA1
ORGANISM(S): Cellular Organisms 
2023-11-11 | PXD038097 | JPOST Repository
ProteomicsHuman HDL 2D-LC-MS/MS
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CH...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080857 | MassIVE
TranscriptomicsMicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins
This SuperSeries is composed of the following subset Series: GSE25108: MicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (Human HDL miRNA Signatures) GSE25110: MicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipopro...
ORGANISM(S): Homo sapiens 
2011-04-03 | E-GEOD-25425 | biostudies-arrayexpress
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