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MetabolomicsMetabolomic Fingerprinting of Human High Grade Serous Ovarian Carcinoma Cell Lines
Not available
ORGANISM(S): Homo sapiens 
ST001983 | MetabolomicsWorkbench
MetabolomicsTime-Resolved Metabolomics of a Mouse Model of Ovarian High-Grade Serous Carcinoma (LC-MS)
Not available
ORGANISM(S): Mus musculus 
ST002067 | MetabolomicsWorkbench
TranscriptomicsmiRNA profiling in high-grade serous ovarian carcinoma
In this study, we performed miRNA profiles analysis of high-grade serous ovarian carcinoma compared to normal fallopian tube fimbria using microarray (Exiqon, Denmark) to evaluate their potential role in the pathogenesis of uterine leiomyoma. miRNA profiling analysis of the 10 samples including 5 h...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-61485 | biostudies-arrayexpress
TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human LMP ovarian tumors and low-grade ovarian carcinomas to identify genes which dffer from high-grade ovarian carcinomas - PAX2: a potential biomarker for low malignant potential ovarian tumors and low-grade serous ovarian carcinomas
Objective: Ovarian tumors of low-malignant potential (LMP) and low-grade serous ovarian carcinomas are thought to represent different stages on a tumorigenic continuum and to develop along pathways distinct from that of high-grade serous ovarian carcinoma. Past studies have utilized gene expression...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-14001 | biostudies-arrayexpress
TranscriptomicsProfiles of genomic instability in high-grade serous ovarian cancer (HGSC) predict treatment outcome
Profiling of loss of heterozygosity (LOH) in HGSC, subcrouping HGSC by LOH-based clustering and comparing to the LOH profiles of triple-negative breast cancer [previously submitted; GSE19594]. Study for the correlation of LOH burdern and LOH-based subgroups to clinical response to platinum-based ch...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-39130 | biostudies-arrayexpress
TranscriptomicsA cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer
Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and 15,500 deaths from ovarian cancer in the country (Siegel et al., 2012). While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of...
ORGANISM(S): Homo sapiens 
2014-09-11 | E-GEOD-40595 | biostudies-arrayexpress
TranscriptomicsNeoadjuvant chemotherapy modulates T cell responses in high-grade serous ovarian cancer metastases
Our data suggest that neoadjuvant chemotherapy enhances anti-cancer responses of T cells in peritoneal metastases of patients with high-grade serous ovarian cancer but does not decrease levels of immune checkpoint molecules, providing a rationale for sequential chemo-immunotherapy. tRNA was isolated...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-71340 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of ovarian tumors from mice with knockout of DICER and PTEN
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-28720 | biostudies-arrayexpress
TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (2)
Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of six microarray datasets consisting of 1054 ova...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32063 | biostudies-arrayexpress
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