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TranscriptomicsTranscription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice
RNA-Seq was performed on pancreatic islets from four transgenic mouse strains affecting LKB1 and AMPK. A conditional LKB1 knockout strain was generated. Double conditional knockouts for AMPK alpha1 and AMPK alpha2 were also generated. These conditional strains were crossed with RIP-Cre (driven by ra...
ORGANISM(S): Mus musculus 
2014-10-25 | E-MTAB-2791 | biostudies-arrayexpress
TranscriptomicsImpaired Chromatin Remodelling at STAT1-Regulated Promoters Leads to Global Unresponsiveness of Toxoplasma gondii-Infected Macrophages to IFN-Gamma
Intracellular pathogens including the apicomplexan and opportunistic parasite Toxoplasma gondii profoundly modify their host cells in order to establish infection. We have shown previously that intracellular T. gondii inhibit up-regulation of regulatory and effector functions in murine macrophages (...
ORGANISM(S): Mus musculus 
2012-01-25 | E-GEOD-28499 | biostudies-arrayexpress
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