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TranscriptomicsResponse of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer.
Objectives ELB-21 is a pyrrolo[2,1-c][1,4]benzodiazepine dimer with potent antistaphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory proteins and transcription elongation in a sequence-selective manner. Transcriptional and pro...
ORGANISM(S): Staphylococcus aureus 
2009-09-18 | E-BUGS-79 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (microRNA)
Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expr...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47053 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (mRNA)
Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expr...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from T1 alpha (-/-) vs. wild type at fetal and term developmental stages
We compared gene expression in T1alpha (-/-) lungs vs wild type at dpc 18.5 when the phenotype is moderate and at term when the phenotype is more severe. Lungs present narrow and irregular alveolar spaces, thicker mesenchyme, reduced number of attenuated type I cells, normal numbers of type II cells...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-1363 | biostudies-arrayexpress
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