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MetabolomicsGNPS - Defective pgsA contributes to increased membrane fluidity and cell wall thickening in S. aureus with high-level daptomycin resistance
Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant Staphylococcus aureus. In the rare event of failed daptomycin therapy, the source of resistance is often attributable to mutations directly with...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2023-04-12 | MSV000091690 | GNPS
MetabolomicsGNPS Revealing fatty acid heterogeneity in Staphylococcal lipids with isotope labeling and RPLC-IM-MS
Up to 80% of the fatty acids in Staphylococcus aureus membrane lipids are branched, rather than straight-chain, fatty acids. The branched fatty acids (BCFAs) may have either an even or odd number of carbons and the branch position may be at the penultimate carbon (iso) or the antepenultimate (anteis...
ORGANISM(S): Staphylococcus Aureus 
2021-05-03 | MSV000087356 | GNPS
MetabolomicsGNPS - Lipidomics of homeoviscous adaptation to low temperatures in Staphylococcus aureus utilizing exogenous straight-chain unsaturated fatty acids over biosynthesized endogenous branched-chain fatty acids
It is well established that Staphylococcus aureus can incorporate exogenous straight-chain unsaturated fatty acids (SCUFAs) into membrane phospho- and glyco-lipids from various sources in supplemented culture media, and when growing in vivo in an infection. Given the enhancement of membrane fluidity...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2024-05-10 | MSV000094738 | GNPS
UnknownHuman kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.
Not available
S-EPMC6338315 | biostudies-literature
UnknownGenome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Not available
S-EPMC3712260 | biostudies-literature
UnknownUse of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial.
Not available
S-EPMC4303045 | biostudies-literature
UnknownMeta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
Not available
S-EPMC5299468 | biostudies-literature
UnknownConservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial.
Not available
S-EPMC12163715 | biostudies-literature
UnknownOlfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.
Not available
S-EPMC12464792 | biostudies-literature
UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Not available
S-EPMC11408082 | biostudies-literature
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