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TranscriptomicsStpA prevents RpoS-dependent transcription during mid-exponential growth in S. Typhimurium
StpA is a paralogue of the nucleoid associated protein H-NS that is conserved in a range of enteric bacteria and had no known function in Salmonella enterica serovar Typhimurium. Here, we show that 5% of the Salmonella genome is regulated by StpA, which contrasts with the situation in Escherichia co...
ORGANISM(S): Salmonella typhimurium SL1344 
2010-06-20 | E-GEOD-18428 | biostudies-arrayexpress
TranscriptomicsEffect of ppGpp on Salmonella Typhimurium gene expression
The expression profile of an S. Typhimurium mutant strain unable to synthesise ppGpp (relAspoT deletions) was compared to the wild-type strain. The effect of ppGpp on virulence gene expression was studied under 4 different growth conditions that induce virulence gene expression. Keywords: genetic mo...
ORGANISM(S): Salmonella typhimurium 
2010-06-11 | E-GEOD-4631 | biostudies-arrayexpress
TranscriptomicsThe effect of stpA deletion on S. Typhimurium gene expression during growth in rich medium
StpA is a paralogue of the nucleoid associated protein H-NS that is conserved in a range of enteric bacteria and had no known function in Salmonella enterica serovar Typhimurium. Here, we show that 5% of the Salmonella genome is regulated by StpA, which contrasts with the situation in Escherichia co...
ORGANISM(S): Salmonella typhimurium SL1344 
2009-10-27 | E-GEOD-18424 | biostudies-arrayexpress
TranscriptomicsRole of stpA in Salmonella typhimurium
This SuperSeries is composed of the following subset Series: GSE18424: The effect of stpA deletion on S. Typhimurium gene expression during growth in rich medium GSE18428: StpA prevents RpoS-dependent transcription during mid-exponential growth in S. Typhimurium GSE18450: Identification of StpA-bind...
ORGANISM(S): Salmonella typhimurium SL1344 
2010-06-21 | E-GEOD-18452 | biostudies-arrayexpress
TranscriptomicsCoding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation
It is well established that small noncoding RNAs (sRNAs) of bacteria recognize the 5â?? regions of target mRNAs, generally at the ribosome binding site. Until now, the translated coding sequence (CDS) of mRNA appeared to be refractory to sRNA interactions. We have discovered that Salmonella MicC RNA...
ORGANISM(S): Salmonella enterica 
2010-05-16 | E-GEOD-16540 | biostudies-arrayexpress
TranscriptomicsThe nucleoid-associated protein HU controls three regulons that coordinate virulence and general physiology in Salmonella enterica serovar Typhimurium
The regulon of genes controlled by the HU nucleoid-associated proteins was examined in Salmonella enterica serovar Typhimurium (S. Typhimurium). DNA microarrays were used to detect the effect on the bacterial transcriptome of knockout mutations in the hupA, the hupB and in both the hupA and hupB gen...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-03-22 | E-GEOD-22860 | biostudies-arrayexpress
TranscriptomicsSpecific and pleiotropic patterns of mRNA regulation by ArcZ
The small RNA, ArcZ (previously RyhA/SraH), was discovered in several genome-wide screens in Escherichia coli and Salmonella. Its high degree of genomic conservation, its frequent recovery by shotgun sequencing, and its association with the RNA chaperone, Hfq, identified ArcZ as an abundant enteroba...
ORGANISM(S): Salmonella enterica 
2009-10-19 | E-GEOD-17771 | biostudies-arrayexpress
TranscriptomicsThe transcriptional programme of Salmonella Typhimurium reveals a key role for tryptophan metabolism in biofilms
Background: Biofilm formation by Salmonella species enhances the capacity of these pathogenic bacteria to survive stresses that are commonly encountered within food processing and during host infection. The persistence of Salmonella within the food chain has become a major health concern, as biofilm...
ORGANISM(S): Salmonella enterica 
2010-05-18 | E-GEOD-17246 | biostudies-arrayexpress
TranscriptomicsIdentification of StpA-binding sites on the Salmonella genome
We used ChIP-chip analysis to identify where the nucleoid associated protein StpA binds on the Salmonella Typhimurium genome. We identified 285 chromosomal regions bound by StpA, ranging in size from 400 to 3500 base pairs and containing 572 genes. Comparison of the ChIP data revealed that StpA disp...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2009-10-28 | E-GEOD-18450 | biostudies-arrayexpress
TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
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