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ProteomicsHigh persister protein kinase HipA and its gain-of-function variant HipA7 phosphorylate different substrate pools in Escherichia coli
Bacterial persistence, the ability to survive antibiotic treatment by entering a physiologically dormant state, is a serious biomedical problem. Protein Ser/Thr kinase HipA, the first toxin connected to bacterial multidrug tolerance (persistence), exerts its function by phosphorylating glutamate--tR...
ORGANISM(S): Escherichia coli 
2018-09-17 | PXD009173 | Pride
E. coli Silac Hipa kinase Phosphoproteome 
ProteomicsNeutralization mechanism of a HipA-like toxin targeting isoleucyl-tRNA synthetase
HipAB is a type II toxin-antitoxin (TA) system that targets and inactivates specific aminoacyl-tRNA synthetases in response to various stresses. While the molecular targets and neutralization mechanisms of several HipAB-like TA systems have been well characterized, their structural and functional di...
ORGANISM(S): Escherichia Coli K-12 
2025-04-11 | PXD062828 |
ProteomicsHomologous HipA-like kinases are controlled by internal translational initiation and genetic organisation
HipA-like kinases are widespread bacterial serine-threonine kinases, yet their regulatory mechanisms remain poorly understood. Here, we characterise two novel HipA-like systems, the monocistronic hipL and bicistronic hipIN, containing a HipS-like and a HIRAN domain. We show that hipL contains an int...
ORGANISM(S): Escherichia coli 
2025-12-15 | PXD065186 | Pride
Trna synthetase E. coli Toxin-antitoxin Hipbst Protein kinase Hipba 
UnknownMolecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Not available
S-EPMC2764309 | biostudies-literature
ProteomicsSerine-Threonine Kinase Encoded by a Split hipA Homologous Gene of Escherichia coli Inhibits Tryptophanyl-tRNA Synthetase
Type II toxin – antitoxin modules encode a stable toxin that inhibits translation, replication or cell wall synthesis and an unstable protein antitoxin that neutralizes the toxin by direct protein – protein contact. The hipBA module of Escherichia coli K-12 codes for HipA, a eukaryote-like serine/th...
ORGANISM(S): Escherichia coli 
2019-06-24 | PXD012023 | Pride
E. coli Kinase Phosphorylation 
UnknownNovel Inhibitors of Toxin HipA Reduce Multidrug Tolerant Persisters.
Not available
S-EPMC4867474 | biostudies-literature
Genomics
Antibiotic resistance E. coli hipA KO strain
PRJNA1019265 | ENA
UnknownKinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli.
Not available
S-EPMC1698217 | biostudies-literature
UnknownSerine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase.
Not available
S-EPMC6581861 | biostudies-literature
UnknownPhylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations.
Not available
S-EPMC8262856 | biostudies-literature
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