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TranscriptomicsG9a selectively represses a class of late-replicating genes at the nuclear periphery (WG_CGH)
We have investigated the role of the histone methyltransferase G9a in the establishment of silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in mouse ESCs, 167 genes were significantly up-regulated, and no genes were strongly down-regulated. A partially overlap...
ORGANISM(S): Mus musculus 
2009-11-02 | E-GEOD-18079 | biostudies-arrayexpress
TranscriptomicsG9a selectively represses a class of late-replicating genes at the nuclear periphery
This SuperSeries is composed of the following subset Series: GSE18076: G9a selectively represses a class of late-replicating genes at the nuclear periphery (Expression) GSE18079: G9a selectively represses a class of late-replicating genes at the nuclear periphery (WG_CGH) Refer to individual Series
ORGANISM(S): Mus musculus 
2009-11-02 | E-GEOD-18082 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis
This SuperSeries is composed of the following subset Series: GSE17980: Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (Expression) GSE17983: Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (WG_CGH; Replicati...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-18019 | biostudies-arrayexpress
TranscriptomicsReplication Timing Reveal An Epigenetic Commitment To Differentiation Prior To Germ Layer Specification (WG_CGH, RT)
Differentiation of mouse embryonic stem cells (mESCs) is accompanied by global changes in replication timing. To elucidate this reorganization process and explore its potential impact on mouse development, we constructed genome-wide replication-timing profiles of 15 independent mouse cell types repr...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-17983 | biostudies-arrayexpress
TranscriptomicsG9a selectively represses a class of late-replicating genes at the nuclear periphery (Expression)
We have investigated the role of the histone methyltransferase G9a in the establishment of silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in mouse ESCs, 167 genes were significantly up-regulated, and no genes were strongly down-regulated. A partially overlap...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-18076 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (Expression)
Differentiation of mouse embryonic stem cells (mESCs) is accompanied by changes in replication timing. To explore the relationship between replication timing and cell fate transitions, we constructed genome-wide replication-timing profiles of 22 independent mouse cell lines representing 10 stages of...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-17980 | biostudies-arrayexpress
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